Prakt. lékáren. 2006; 2(2): 63-65

Probiotika v profylaxi a terapii nádorových onemocnění a vulvovaginitid

PharmDr. Miloslav Hronek Ph.D1, Mgr. Zdeňka Kudláčková1, PharmDr. Petr Jílek CSc1, MUDr. Dana Hrnčiariková2
1 Farmaceutická fakulta, katedra biologických a lékařských věd, Hradec Králové
2 Klinika gerontologická a metabolická, FN Hradec Králové

Z hlediska protinádorových účinků hrají probiotika nejdůležitější roli v profylaxi patogeneze kolorektálního nádoru. Protinádorové vlastnosti probiotik se uplatňují při inhibici genotoxicity karcinogenů a supresi karcinogenem indukovaných preneoplastických lézí a nádorů. V profylaxi vaginálních kandidóz se doporučuje perorální podávání kmenů Lactobacillus rhamnosus GR-1 a L. fermentum RC-14, B-54. Dále se jeví vhodné kmeny L. brevis CD-2, L. salivarius FV-2, L. gasseri MB 335, L. plantarum, a to v podobě gelových kapslí (L. plantarum) či vaginálních tablet (L. gasseri). Kmeny L. acidophilus CRL 1294 a L. salivarius CRL 1328 vykazují schopnost samoagregace a koagregace s Candidou. Probiotické kmeny lactobacilla mohou ve vzácných případech vyvolat bakteriémii a sepsi, a to zejména u imunodeficientních pacientů a pacientů, kteří prodělali chirurgický zákrok trávicího traktu. Kmeny, které infekci způsobily byly: L. casei a L. rhamnosus.

Keywords: probiotika, nádorová onemocnění, vulvovaginitis, Lactobacillus

Published: September 1, 2006  Show citation

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Hronek M, Kudláčková Z, Jílek P, Hrnčiariková D. Probiotika v profylaxi a terapii nádorových onemocnění a vulvovaginitid. Praktické lékárenství. 2006;2(2):63-65.
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