Prakt. lékáren. 2009; 5(2): 92-95

Inhibition of α-amylase and α-glucosidase with natural substances

Mgr. Jan Martin Ph.D, doc. RNDr. Jaroslav Dušek CSc
Katedra farmakognosie, FaF v Hradci Králové

Human nutrition consists of three main components: saccharides, lipids, and proteins. Saccharides account for as much as 60 percent

and most of this amount comes in the form of starches. By using enzymes (amylases and glucosidases), the digestive system breaks

down this polysaccharide into glucose which is the basic source of energy for animal cells.

The inhibition of amylases and glucosidases decreases the biological availability of glucose, thus reducing postprandial hyperglycaemia

(elevated blood glucose after a meal). These inhibitors may play a significant role in diagnosing and treatment of diabetes and obesity.

Substances having this effect are also found in certain plants and have been intensively studied recently.

Keywords: α-amylase, α-glucosidase, inhibitors, 1-deoxynojirimycin, anthocyans, procyanidins.

Published: April 1, 2009  Show citation

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Martin J, Dušek J. Inhibition of α-amylase and α-glucosidase with natural substances. Praktické lékárenství. 2009;5(2):92-95.
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