Prakt. lékáren. 2010; 6(5): 244-249

New medicinal substances in extemporaneous prescription, part 3 - Clotrimazole

PharmDr.Jan Hašek1, PharmDr.Zbyněk Sklenář, Ph.D.2
1 Lékárna U Matky Boží, Doksy
2 Vyšší odborná škola zdravotnická, Plzeň

The present article provides information on the properties and use of clotrimazole in the treatment of mycotic diseases of the skin

and mucosae. The introduction summarizes the basic galenical properties and possibilities of formulating clotrimazole in medicinal

products; next, examples of formulas are presented which are suitable for pharmacy compounding. Combinations of clotrimazole

with other drugs are frequently ordered by physicians in prescriptions for customized medications which, however, have so far been

preparable only when using proprietary creams containing clotrimazole. The use of the pharmaceutical substance allows not only to

prescribe and then to prepare a combined dermatological external drug with a specific stability as well as to preserve the therapeutic

concentration of medicinal substances, but also to prepare solutions for oral and aural administration which are currently not available

in the form of proprietary medicinal products.

Keywords: clotrimazole, antifungal drugs, customized preparation, stability, tinea, onychomycoses

Published: October 19, 2010  Show citation

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Hašek J, Sklenář Z. New medicinal substances in extemporaneous prescription, part 3 - Clotrimazole. Praktické lékárenství. 2010;6(5):244-249.
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