Prakt. lékáren. 2011; 7(4): 172-175

The question of pharmacological treatment in selected diseases and drug groups

David Suchý, Milan Hromádka
1 Oddělení klinické farmakologie, Fakultní nemocnice v Plzni
2 I. interní klinika, Fakultní nemocnice v Plzni

Elderly patiens are more than twice as susceptible to averse drug reaction as younger patiens. These reactions are likely to be more serious

and extend hospitalization longer, that for a younger patiens. Changes with aging in body composition, and in drug metabolism,

distribution, excretion and response are the reasons for greater vulnerability observed in this patiens. Use of potentially inappropriate

medication in elderly patiens is a major health care concern. There is need avoiding medications with a high potential for averse events

and recommended alternatives with lower risc.

Keywords: treatment in the elderly, potentially inappropriate drugs, adverse drug reactions

Published: August 10, 2011  Show citation

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Suchý D, Hromádka M. The question of pharmacological treatment in selected diseases and drug groups. Praktické lékárenství. 2011;7(4):172-175.
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    References

    1. Vítovec J, Špinar J. Problematika farmakologické léčby kardiovaskulárních onemocnění u starších nemocných. Čes Ger Rev 2005; 3(4): 8-16.
    2. Hradec J. Digoxin v léčbě chronického srdečního selhání. Argumenty pro a proti. Kapitoly z kardiologie 2002; 4: 82-88.
    3. Léčiva potencionálně nevhodná ve stáří I, II. Farmakoterapeutické informace 10/11 2006.
    4. Eybl V, Černá P. Základy geriatrické farmakologie. Praha, Karolinum 2008. Grundmann M. Lékové interakce I. Interní Med Prax 2002; 2: 40-49.
    5. Kriška M, et al. Memorix klinickej farmakologie a liekov. II ed. Bratislava, SAP 2006.
    6. Hanratty CG, Mc Glinchey P, Johnston GD, Passmore AP. Differential pharmacokinetics of digoxin in elderly patients. Drugs Aging 2000; 17(5): 353-362. Go to original source... Go to PubMed...
    7. Capucci A, Aschieri D, Viliam GQ. Clinical Pharmacology of Antiarrhythmic Drugs. Drugs & Aging 1998; 13(1): 51-70. Go to original source... Go to PubMed...
    8. Fialová D. Specifické rysy geriatrické farmakoterapie I. Změna terapeutické hodnoty léků ve stáří. Praha, Karolinum 2007.
    9. Ohyama K, et al. Inhibitory effects of amiodarone and its N-deethylated metabolite on human cytochrome P450 activities: prediction of in vivo drug interactions. Br J Clin Pharmacol 2000; 49: 244-253. Go to original source... Go to PubMed...
    10. Janota T, Malík J, Holaj R, Šimek J. Méně obvyklé nežádoucí účinky amiodaronu. Interní Med Prax 2006; 11: 513-514.
    11. Lejčko J. Postavení opioidů v léčbě chronické bolesti. Medicína po promoci 2008; Suppl 4: 35-42.
    12. Topinková E. Racionální farmakoterapie ve stáří. In: Topinková E. Geriatrie pro praxi Praha: Galén, 2005: 13-19.
    13. Edvardsson N, Juul-Moller S, Omblus R, Pehrsson K. Effects of low-dose warfarin and aspirin versus no treatment on stroke in a medium-risc patient population with atrial fibrillation. J Intern Med 2003; 254(1): 95-101. Go to original source... Go to PubMed...
    14. Monti DA. Practical geriatrics. Management of chronic pain among elderly patiens. Psychiatr Serv 1998; 49: 1537-1539. Go to original source... Go to PubMed...
    15. Weber P, Kriška M, Meluzínová H, Dítětová K, Wawruch M. Polyfarmakoterapie v klinické gerontologii. Čas Lék Čes 2004; 143(8): 547-551.
    16. Kasalová Z, Kasalová Z jr. Ambulantní léčba hluboké žilní trombózy. Interní Med Prax 2006; 2: 58-61.
    17. Čepelák V. Prevence rizika hluboké žilní trombózy u interních nemocných. Interní medicína pro praxi 2000; 2(5): 5-77.
    18. Chlumský J, a kol. Antikoagulační léčba Praha, Grada 2005.
    19. Štolfa J. Léčba nesteroidními antirevmatiky/antiflogistiky ve stáří. Farmakoterapie 2006; 1: 72-79.
    20. McLeod PJ, Huang AR, Tamblyn RM, Gayton DC. Defining inappropriate practices in prescribing for elderly people: a national consensus panel. CMAJ 1997; 56: 385-391.
    21. Wawruch M, Foltánová T, Žikavská M, et al. Indikátory kvality farmakoterapie v geriatrii. Klin Farmakol Farm 2006; 20(3): 135-139.

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