Prakt. lékáren. 2011; 7(5): 236-238

New medicinal substances in extemporaneous prescription, part 11 - domperidone

Zbyněk Sklenář^1,2,3, Kateřina Horáčková³

¹ Farmakologický ústav, 1. LF UK, Praha

² Vyšší odborná škola zdravotnická, Plzeň

³ Lékárna Na Rohožníku, Praha

Domperidone is an effective substance used in adults and children, in the Czech Republic available in commercial products as 10-mg oral

tablets only. To apply different doses or different dosage forms, a special import from abroad is possible or extemporaneous preparation

may be offered. In pediatric practice, rectal suppositories or oral dosage forms are required; in adults, rectal suppositories with a higher

amount of active substance are used. Since mid-July 2011, domperidone has been available as a pharmaceutical substance for the extemporaneous

preparation in pharmacies and the preparation of such formulations and such dosages required for a specific patient has

been possible. The paper provides information on the properties and use of domperidone and presents examples of formulas suitable for

magistral preparation, which in turn increases the importance of individualized pharmacotherapy.

Keywords: antiemetic drug, domperidone suppositories, domperidone oral suspension, magistral preparation, pediatric dosage forms

Published: November 1, 2011  Show citation