Prakt. lékáren. 2011; 7(6): 276-278

Extemporaneously prepared pediatric dosage forms - part 1

Sylva Klovrzová
Nemocniční lékárna Fakultní nemocnice v Motole, Praha

This article summarizes possibilities of small scale preparation of non-sterile dosage forms with systemic effects designed for pediatric

population. Suitability of dosage form depends on route of administration, age of children and physical-chemical and biopharmaceutical

properties of drug substance. If the active pharmaceutical ingredient (API) is not available as a raw material, it is possible, under certain

circumstances, to modify the licensed product to suitable form for pediatric administration with required dosage of API. The pharmacist

is responsible for quality, stability and content of drug during shelflife.

Keywords: extemporaneous preparation, paediatrics, dosage form, stability

Published: December 1, 2011  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Klovrzová S. Extemporaneously prepared pediatric dosage forms - part 1. Praktické lékárenství. 2011;7(6):276-278.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. MV-AISLP pro Windows, verze 2.2010.
    2. Lain A, Rezepturen fur Kinder, 3. ZetA-Akademie Weimar 18.-19. 9. 2010; dostupné na http://www.pharmazeutischezeitung.de/fileadmin/nrf/pdf/Vortrag_Zeta.pdf - navštíveno 2. 2. 2011.
    3. Note for Guidance on Clinical Investigation of Medicinal Products in the Pediatric Population, CPMP/ICH/2711/99, EMEA 2000; dostupné na http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500002926.pdf - navštíveno 10.9.2011.
    4. Reflection Paper: Formulations of choice for the pediatric population, EMEA/CHMP/PEG/194810/2005, EMEA 2006; dostupné na http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500003782.pdf - navštíveno 10. 9. 2011.
    5. Vyhláška č. 84 ze dne 26. února 2008 O správné lékárenské praxi, bližších podmínkách zacházení s léčivy v lékárnách, zdravotnických zařízeních a u dalších provozovatelů a zařízení vydávajících léčivé přípravky. In: Sbírka zákonů České republiky. 2008, částka 25, s. 1104-1125; dostupné na http://aplikace.mvcr.cz/archiv2008/sbirka/2008/sb025-08.pdf - navštíveno 1. 3. 2011.
    6. Komárek P, Rabišková M. Technologie léků, 3. vydání, Galén 2006: 399.
    7. Český lékopis 2009 - Doplněk 2010, Grada Publishing, a.s., Praha 2010: 5357.
    8. LEK-5 verze 2 - Doporučené doby použitelnosti léčivých přípravků připravovaných v lékárně (platnost od 1. 10. 2009); dostupné na http://www.sukl.cz/lekarny/lek-5-verze-2 - navštíveno 11. 2. 2011.
    9. Deutscher Arzneimittel-Codex (DAC)/Neues RezepturFormularium (NRF) 2009, Govi-Verlag Eschborn, Deutscher Apotheker-Verlag Stuttgart 2009.
    10. Československý lékopis 4, Svazek III., Avicenum-Zdravotnické nakladatelství, n.p., Praha 1987: 15.

    Return to the content


    Pharmacy for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.