Prakt. lékáren. 2012; 8(3): 107-108

Pharmacotherapy of Alzheimer disease

Roman Jirák
Psychiatrická klinika 1. LF UK a VFN Praha

Exact cause of Alzheimer disease is not yet known, there are known only separate pathogenetic links and some of their connections. This

knowledge results in the current therapy. Current therapeutic approaches are only symptomatic and disease – modifying, not causal.

Only use of brain cholinesterases inhibitors and mild NMDA glutamatergic receptor blocker memantine is evidence-based.

Keywords: donepezil, galantamine, acetylcholinesterase inhibitors, memantine, rivastigmine

Published: May 14, 2012  Show citation

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Jirák R. Pharmacotherapy of Alzheimer disease. Praktické lékárenství. 2012;8(3):107-108.
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References

  1. Birks J. Cholinesterase inhibitors for Alzheimer´s disease, Cochrane Database of Systematic Reviews 2006; 1, Art No: CD0055 93, DOI: 10.1002/14651858. CD0055 93. Go to original source... Go to PubMed...
  2. Black SE, Doody R, Li H, et al. Donepezil preserves cognition and global function in patients with severe Alzheimer disease. Neurology 2007; 69(5): 459-468. Go to original source... Go to PubMed...
  3. DeKosky ST, Williamson JD, Fitzpatrick AL, et al. Ginkgo biloba for prevention of dementia. A randomized controlled trial. JAMA 2008; 300(19): 2253-2262. Go to original source... Go to PubMed...
  4. Jirák R, Seifertová D, Praško J, Franková V. Organicky podmíněné psychické poruchy. In: Konziliární psychiatrie, ed. Herman E, Praško J, Seifertová D. Medical Tribune, Praha, 2008: 52-65.
  5. Jirák R, Franková V. Demence a jiné organicky podmíněné poruchy. In: Seifertová D, Praško J, Horáček J, Höschl C, a kol. Postupy v léčbě psychických poruch. Algoritmy České neuropsychofarmakologické společnosti. Medical Tribune CZ, Praha, 2008: 12-29.
  6. Jirák R, Franková V. Demence. In: Raboch J, Anders M, Hellerová P, Uhlíková P, (eds.) a kol. Psychiatrie. Doporučené postupy psychiatrické péče III. Psychiatrická společnost ČLS JEP, Česká Psychiatrická společnost o. s., 2010: 20-53.
  7. Lemere CA, Masliah E. Can Alzheimer disease be prevented by amyloid-beta immunotherapy? Nat Rev Neurol 2010; 6(2): 108-119. Go to original source... Go to PubMed...
  8. National Institute for Health and Clinical Excellence: Donepezil, galantamine, rivastrigmine (review) and memantine for the treatment of Alzheimer´s disease (amended). Includes a review of NICE technology appraisal guidance 19. Issue date: Nov. 2006 (amended Sept. 2007).
  9. Peskind ER, Potkin SG, Pomara, et al. Memantine treatment in mild to moderate Alzheimer disease: a 24 week randomized controlled trial. Am J Geriatr Psychiatry 2006; 14(8): 704-715. Go to original source... Go to PubMed...
  10. Waldemar G, Dubois B, et al. Recommendations for the diagnosis and management of Alzheimer´s disease and other disroders associated with dementia: EFNS guideline. Eur J Neurol 14(1): 1-26.




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