Prakt. lékáren. 2012; 8(3): 118-122

Specifics of pharmacotherapy in neonates

Petra Thomson
Resident Pharmacist, Great Ormond Street Hospital NHS Foundation Trust, London, The United Kingdom

The first month of life is a phase of rapid growth and development, making the understanding of pharmacokinetics in neonates a unique

challenge. Extrapolating adult medicine dose to neonates is rarely possible in practice. This article outlines basic pharmacokinetic

principles in newborns, its impact on pharmacotherapeutical management and some common reasons for admission of neonates to

neonatal intensive care units. These specific pharmaceutical issues present great scope for pharmacists to contribute to the safe and

effective treatment of neonates.

Keywords: neonate, pharmacokinetics, therapy, pharmacology, pharmacy, complication, vitamins

Published: May 14, 2012  Show citation

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Thomson P. Specifics of pharmacotherapy in neonates. Praktické lékárenství. 2012;8(3):118-122.
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    References

    1. Child health. First month of life. An open learning programme for pharmacists and pharmacy technicians. CPPE, The University of Manchester, 2006: 45-53.
    2. Skinner AV. Neonatal pharmacology. Aneasthesia and Intensive Care Medicine 2010; 12: 3. Go to original source...
    3. Cote CJ, Lerman J, Ward RM, Lugo RA, Goudsouzian N. Pharmacokinetics and pharmacology of drugs used in children. In: Cote CJ, Lerman J, Todres ID, eds. A practice of anaesthesia for infants and children. 4th edition, Elsevier, 2008. Go to original source...
    4. Sumpter A, Anderson BJ. Pediatric pharmacology in the first year of life. Curr Opin Anaesthesiol 2009; 22: 469e75. Go to original source... Go to PubMed...
    5. Costello I, Long PF, Wong IK, Tuleu C, Yeung V. Paediatric Drug Handling. Pharmaceutical Press, 2007.
    6. European Medicines Agency. Guideline on the investigation of Medicinal Products in the term and preterm Neonate, London, October 2007. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500003754.pdf.

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