Prakt. lékáren. 2013; 9(3): 123-126

Drug-induced liver injury

Petr Červený
Ústavní lékárna FN Plzeň, Bory

The liver is the largest organ in the human body. It plays an essential role in the metabolism, synthesis, and storage of endogenous

compounds as well as in detoxication and excretion of exogenous compounds. Hepatotoxicity refers to liver injury due to exposure to

a chemical substance; iatrogenic injury is that which is induced by medicinal products. Medicinal products may have hepatotoxic effects

not only as a result of overdose but, in many cases, even when used in therapeutic doses. The article deals with individual mechanisms

of liver injury and particular drug groups.

Keywords: liver, iatrogenic injury, hepatotoxicity, paracetamol, antituberculotics

Published: July 15, 2013  Show citation

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Červený P. Drug-induced liver injury. Praktické lékárenství. 2013;9(3):123-126.
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