Prakt. lékáren. 2013; 9(4-5): 192-195

New medicinal substances in extemporaneous prescription - miconazole and miconazole nitrate

Jan Hašek

Lékárna U Matky Boží, Doksy

Miconazole is the second azole antifungal drug and the third specific antifungal agent in succession among the newly available pharmaceutical

substances that are currently available for extemporaneous preparation in pharmacies. It has a fungistatic to fungicidal activity,

acting even on gram-positive bacteria. The article deals with the pharmacotherapeutic and galenic properties of this substance.

Attention is paid to formulas for the treatment of oropharyngeal candidiases – hydrophilic gel with miconazole, and the treatment of

dermatomycoses – hydrophilic creams, ointment. Technologically, miconazole and miconazole nitrate are relatively stable pharmaceutical

substances; they are stable not only at higher temperatures, but also, in contrast to clotrimazole, in a wider range of pH.

Keywords: miconazole, azole antifungals, oral candidiasis, diaper dermatitis, extemporaneous preparation

Published: October 15, 2013  Show citation