Prakt. lékáren. 2014; 10(5): 190-192

Adverse and toxic effects of standard herbal drug overdose

Jan Martin1, Denisa Diblíková2
1 Katedra farmakognozie, Farmaceutická fakulta v Hradci Králové, Univerzita Karlova v Praze
2 Lékárna Vital, OC Atrium, Hradec Králové

The use of natural substances for the treatment has not only the advantages, but unfortunately some risks as well. Patients often do not

realize the risks and believe that the effect of herbal drugs multiply by increasing the dosage. There can be achieved a toxic level of some

constituent of medicinal plant by this way.

The first part of this article includes toxic effects of plants used as medicines and food: ginger, sage, licorice and soya.

Keywords: ginger, sage, licorice, soya, overdose, toxicity

Published: October 24, 2014  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Martin J, Diblíková D. Adverse and toxic effects of standard herbal drug overdose. Praktické lékárenství. 2014;10(5):190-192.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Ding M, Leach M, Bradley H. The effectivness and safety of ginger for pregnancy-induced nauzea and vomiting: A systematic review. Women and Birth 2013; 26: 26-30. Go to original source... Go to PubMed...
    2. Chrubasik S, Pittler MH, Roufogalis BD. Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles. Phytomedicine 2005; 12: 684-701. Go to original source... Go to PubMed...
    3. Ding M, et al. A systematic review of the evidence for topical use of ginger. Explore 2013; 9(6): 361-364. Go to original source... Go to PubMed...
    4. Suchopár J, et al. Volně prodejné přípravky v praxi lékárníka a lékaře. Praha: Edukafarm 2011: 77, 111, 217, 309.
    5. Halicioglu O, et al. Toxicity of Salvia officinalis in a newborn and a child: An alarming report. Pediatric Neurology 2011; 45: 259-260. Go to original source... Go to PubMed...
    6. Lachenmeier DW, Uebelacker M. Risk assessment of thujone in foods and medicines containing sage and wormwood - Evidence for a need of regulatory changes? Regulatory Toxicology and Pharmacology 2010; 58: 437-443. Go to original source... Go to PubMed...
    7. Munro IC, et al. Soy isoflavones: A safety review. Nutrition Reviews 2033; 61(1): 1-33. Go to original source... Go to PubMed...
    8. Miniello VL, et al. Soy-based formulas and phyto-oestrogens: a safty profile. Acta Paediatrica Supplement 2003; 441: 93-100. Go to original source... Go to PubMed...
    9. Fukuda I, et al. Oral toxicological studies of black soybean (Glycine max) hull extract: Acute studies in rats and mice, and chronic studies in mice. Food and Chemical Toxicology 2011; 49: 3272-3278. Go to original source... Go to PubMed...
    10. United States Department of Agriculture -Iowa State University. USDA Database for the Isoflavone Content of Selected Foods, Release 2.0, 2008. Dostupné z: http://www.ars.usda.gov/SP2UserFiles/Place/12354500/Data/isoflav/Isoflav_R2.pdf.
    11. Isbrucker RA, Burdock GA. Risk and safety assessment on the consumption of licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxikology of glycyrrhizin. Regulatory Toxicology and Pharmacology 2006; 46: 167-192. Go to original source... Go to PubMed...
    12. Cantelli-Forti G, et al Toxicological assessment of liquorice: biliary excretion in rats. Pharmacological Research 1997; 35: 463-470. Go to original source... Go to PubMed...
    13. Martin M, Burgess J, Haley J. Cankermelts patches reduce pain and speed resolution of aphthous ulcers. Journal of Dental Research 2007; 86(6): 1207-1212. Go to original source... Go to PubMed...
    14. Mills S, Bone K. The Essential Guide to Herbal Safety. London: Elsevier - Churchill Livingstone 2005: 498.
    15. Carmines EL, Lemus R, Gaworski CL. Toxicologic evaluation of licorice extract as a cigarette ingredient. Food and Chemical Toxicology 2005; 43: 1303-1322. Go to original source... Go to PubMed...
    16. Monder C, et al. Licorice inhibits corticosteroid 11 beta-dehydrogenase of rat kidney and liver: in vivo and in vitro studies. Endocrinology 1989; 125: 1046-1053. Go to original source... Go to PubMed...
    17. Johns C. Glycyrrhizic acid toxicity caused by consumption of licorice candy cigars. Canadian journal of emergency medical care 2009; 11: 94-96. Go to original source... Go to PubMed...
    18. Fraunfelder FW. Ocular side effects from herbal medicines and nutritional supplements. American Journal of Ophthalmology 2004; 138(4): 639-647. Go to original source... Go to PubMed...
    19. Armanini D, Bonanni G. Reduction of Serum Testosterone in Men by Licorice. The New England Journal of Medicine 1999; 341: 1158. Go to original source... Go to PubMed...

    Return to the content


    Pharmacy for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.