Prakt. lékáren. 2015; 11(3): 100-102

Glucose pellets in preventing hypoglycaemia

PharmDr.Aleš Franc, Ph.D., doc.Mgr.Jan Muselík, Ph.D., MUDr.David Neumann, Ph.D., Mgr.Dana Sabadková

Ústav technologie léků Farmaceutická fakulta VFU, Brno

Hypoglycaemia occurs as a result of disproportion between the antidiabetic administered, energy expenditure, and the amount of saccharides

used. The majority of hypoglycaemic events can be predicted since they result from erroneous treatment decisions. However, some

hypoglycaemias arise from the treatment options, and can hardly be managed with lifestyle measures. The aim is to develop a dosage form

containing pellets with delayed glucose release. The dosage form comprises an inert core in the form of a pellet containing glucose coated

with a membrane that releases glucose with a time delay when passing through the gastrointestinal tract. According to diabetological

practice, the periods of, e. g., 2, 3, 4, or 6 hours can be considered appropriate for releasing glucose. Thus, a safe level of blood sugar is warranted

for a required time without disrupting the daily schedule in the diabetic patient.

Keywords: hypoglycaemia, diabetes, pellets, delayed release

Published: May 25, 2015  Show citation