Prakt. Lékáren. 2016; 12(4e) [Interní Med. 2016; 18(1): 6-8]

New options in the treatment of hypercholesterolaemia

Vladimír Soška1, 2, 3, Ondřej Kyselák1
1 Oddělení klinické biochemie, ICRC – oddělení kardiovaskulárních chorob, FN u sv. Anny v Brně
2 Katedra laboratorních metod, LF MU Brno
3 II. interní klinika, LF MU Brno

Statins are the key drugs for LDL-cholesterol lowering: they have a lot of evidences that they decrease not only cholesterol, but also cardiovascularevents and mortality. Second-line choice for lowering LDL-cholesterol is ezetimibe, which is intended to combination with statins.This year were published results of IMPROVE-IT study which showed that addition of ezetimibe to statin has also clinical benefit – decrease ofcardiovascular events. New lipid-lowering drugs are PCSK9-inhibitors, first two of which were already approved for clinical use.

Keywords: hypercholesterolemia, LDL-cholesterol, statins, ezetimibe, PCSK9-inhibitors

Published: September 1, 2016  Show citation

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Soška V, Kyselák O. New options in the treatment of hypercholesterolaemia. Praktické lékárenství. 2016;12(E-verze 4/16):.
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