Prakt. Lékáren. 2016; 12(4e): e20-e26 | DOI: 10.36290/lek.2016.083

Mucoadhesive buccal films – a modern dosage form

Jan Gajdziok

Ústav technologie léků, Farmaceutická fakulta, Veterinární a farmaceutická univerzita Brno

This article aims to provide an overview about mucoadhesive dosage forms applied to the oral cavity, focusing on the innovative formulationsof mucoadhesive films in terms of their advantages, composition, preparation and practical use. Films (patches) composed of mucoadhesivepolymers prepared by any of the established methods (solvent casting, melt-extrusion, etc.) may be promising candidates for oral administrationof many drugs, especially for their flexibility and convenience of use. Other advantages of these formulations include prolongation ofa short retention time of conventional oral dosage forms to the mucosa and administration of precise doses of the drug to the application site.In addition, films are able to cover and protect the surface of mucosal lesions, which helps to reduce pain and improve the treatment efficacy.

Keywords: mucoadhesive films, patches, oral cavity, dosage form, solvent casting, extrusion

Published: September 1, 2016  Show citation