Prakt. lékáren. 2017; 13(4): 169-172 | DOI: 10.36290/lek.2017.065

Gastroesophageal reflux disease – risk drugs and treatment options

Jitka Rychlíčková^1,2

¹ Oddělení klinické farmacie, Lékárna, Nemocnice Hořovice, Hořovice

² Ústav farmakologie, 2. LF UK, Praha

Heartburn, non-cardiac chest pain and regurgitation are symptoms of gastroesophageal reflux. The main cause of reflux seemsto be transient relaxation of the lower esophageal sphincter. The prolonged period of contact between acidic gastric content andesophageal mucosa is the cause of above mentioned symptoms. Pharmacological options to affect lower esophageal sphincterpressure, acidity of gastric content are summarized in order to select the best therapy depending on the nature of the disordersdescribed by the patient, his co-morbidities and co-medications and the possible adverse drug effects.

Keywords: gastroesophageal reflux, lower esophageal sphincter, drug induced esophagitis, acid supression therapy, pharmaceuticalcare

Received: August 21, 2018; Accepted: August 25, 2018; Published: December 1, 2017  Show citation