Prakt. lékáren. 2018; 14(3): 120-126 [Med. praxi. 2017;14(3):142-146]

NSAIDs in the acute pain treatment from the viewpoint of a neurologist

Tomáš Nežádal
Institut neuropsychiatrické péče, Praha

Nonsteroidal anti-inflammatory drugs (NSAIDs) have a common analgesic, antipyretic and at higher doses in particular antiphlogisticeffect that differs this pharmacological group from other non-opioid analgesics. The term non-steroidal define these substancesin 1960 against the steroids administred in rheumatology. These are some of the most commonly used drugs. Neurologist's viewon the NSAIDs is not too revealing, but spectrum of NSAIDs in neurology is wide, with acute and chronic pain conditions, fromvertebral and radicular syndromes to migraines and a large group of other headaches. This insight tries to chart the position ofNSAIDs among other analgesics, their possible side effects and common neurological indications.

Keywords: NSAIDs, side effects, vertebral syndrome, headaches

Published: October 1, 2018  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Nežádal T. NSAIDs in the acute pain treatment from the viewpoint of a neurologist. Praktické lékárenství. 2018;14(3):120-126.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Adam F, Fojtík Z. Neopioidní analgetika - farmakologie a léčebné využití. Postgraduální medicína 2006; 3: 277-286.
    2. Knights KM, Arduino A Mangoni AA, Miners JO. Defining the COX Inhibitor Selectivity of NSAIDs: Implications for Understanding Toxicity. Expert Rev Clin Pharmacol 2010; 3(6): 769-776. Go to original source...
    3. Hinz B, Cheremina O, Brune K. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J 2008; 22(2): 383-390. Go to original source... Go to PubMed...
    4. Fowler CJ. The contribution of cyclooxygenase-2 to endocannabinoid metabolism and action. Br J Pharmacol. 2007; 152(5): 594-601. Go to original source...
    5. Cronstein BN, Sunkureddi P. Mechanistic aspects of inflammation and clinical management of inflammation in acute gouty arthritis. J Clin Rheumatol 2013; 19(1): 19-29. Go to original source...
    6. Higuchi K, Umegaki E, Watanabe T, et al. Present status and strategy of NSAIDs-induced small bowel injury. J Gastroenterol 2009; 44(9): 879-888. Go to original source... Go to PubMed...
    7. Shah SB, Hanauer SB. Treatment of diarrhea in patients with inflammatory bowel disease: concepts and cautions. Rev Gastroenterol Disord. 2007; 7(Suppl 3): 3-10.
    8. Thomas MC. Diuretics, ACE inhibitors and NSAIDs - the triple whammy. Med J Aust 2000; 172(4): 184-185. Go to original source... Go to PubMed...
    9. Baron JA, Sandler RS, Bresalier RS, et al. Cardiovascular events associated with rofecoxib: final analysis of the APPROVe trial. Lancet 2008; 372(9651): 1756-1764. Go to original source...
    10. Gislason GH, Rasmussen JN, Abildstrom SZ, et al. Increased Mortality and Cardiovascular Morbidity Associated with Use of Nonsteroidal Anti-inflammatory Drugs in Chronic Heart Failure. Arch Intern Med 2009; 169(2): 141-149. Go to original source...
    11. Coxib and traditional NSAIDs Trialists Collaboration. Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. Lancet. 2013. Aug 31; 382(9894): 769-779. Go to original source...
    12. Krum H, Swergold G, Gammaitoni A, et al. Blood pressure and cardiovascular outcomes in patients taking nonsteroidal antiinflammatory drugs. Cardiovasc Ther. 2012; 30(6): 342-350. Go to original source...
    13. Gulmez SE, Larrey D, Pageaux GP, et al. Transplantation for Acute Liver Failure in Patients Exposed to NSAIDs or Paracetamol. The Multinational Case Population SALT Study. Drug Saf 2013; 36: 135-144. Go to original source...
    14. Shiri R, Koskimäki J, Häkkinen J, et al. Effect of Nonsteroidal Anti-Inflammatory Drug Use on the Incidence of Erectile Dysfunction. J Urol 2006; 175(5): 1812-1816. Go to original source... Go to PubMed...
    15. Rokyta R, Kršiak M, Kozák J. Bolest. Praha: Tigis 2006: 684 s.
    16. Buzzi MG, Sakas DE, Moskowitz MA. Indometacin and acetylsalicylic acid block neurogenic plasma protein extravasation in rat dura mater. Eur J Pharmacol 1989; 165: 251-258. Go to original source...
    17. Niedermayerová I. Nimesulid v léčbě akutních bolestivých stavů v ordinaci praktického lékaře. Med praxi 2015; 12(2): 72-76.
    18. Affaitati G, Fabrizio A, Lopopolo M, et al. Use of NSAIDs for migraine attacks: Results from retrospective analysis in Italian headache center. Presented in 15th World Congress on Pain, Buenos Aires, October 6-11, 2014.
    19. Giacovazzo M, Gallo MF, Guidi V, et al. Nimesulide in the treatment menstrual migraine. Drugs 1993; 46(Suppl. 1): 140-141. Go to original source... Go to PubMed...
    20. Bendtsen L, Evers S, Linde M, et al. EFNS guideline on thetreatment of tension-type headache. Report of an EFNS task force. Eur J Neurol 2010; 17: 1318-1325. Go to original source...
    21. Mastík J, Novotná I, Fasouli S. Ketoprofen v léčbě chronické bolesti hlavy. Bolest 2003; 6(Suppl. 2): 14.
    22. Moore RA, Chi CC, Wiffen PJ, Derry S, Rice AS. Oral nonsteroidal anti-inflammatory drugs for neuropathic pain. Cochrane Database Syst Rev 2015; (10): CD010902. Go to original source...

    Return to the content


    Pharmacy for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.