Prakt. Lékáren. 2018; 14(2e) [Klin Farmakol Farm. 2017;31(3):16-18]

Magnesium supplementation: pharmacological mechanisms, routes of administration, and pitfalls

Zdeněk Zadák, Alena Tichá, Radomír Hyšpler

Centrum pro výzkum a vývoj, Fakultní nemocnice Hradec Králové

Magnesium is a significant factor in a whole range of metabolic reactions, particularly in energy production, in mitochondrial function, beinga part of enzyme cofactors and modulating the function of transport pumps and cell membrane channels. Magnesium deficiency is verycommon in the population of industrialized countries, ranging around 33% in all male and female age groups. The diagnosis of magnesiumdepletion in the body is difficult, given that this ion is present in biological systems in several fractions and, furthermore, because its maximum is contained intracellularly. The clinical symptomatology of magnesium depletion is very broad, ranging from minimal complaints tolife-threatening arrhythmias. Proper magnesium supplementation follows strict rules, particularly in terms of the route of administration (oralor parenteral).The occurrence of hypomagnesaemia, mainly in industrialized countries, remains a major phenomenon causing substantial health problems,and is underrated from both the clinical and preventive viewpoint.

Keywords: hypomagnesaemia, magnesium supplementation, clinical manifestations

Published: June 20, 2018  Show citation