Prakt. Lékáren. 2018; 14(4e) [Klin Farmakol Farm. 2018;32(3):11-14]

Vedolizumab, its pharmacological profile and therapeutic use

Tomáš Douda
II. interní gastroenterologická klinika, Subkatedra gastroenterologie, Lékařská fakulta UK,
Centrum pro idiopatické střevní záněty, Fakultní nemocnice Hradec Králové

Vedolizumab (VDZ), a humanized monoclonal antibody, is approved for use in ulcerative colitis and Crohn’s disease (IBD).Vedolizumab inhibitsleukocyte vascular adhesion and migration into the gastrointestinal tract through α4β7 integrin blockade. Clinical effectiveness of vedolizumabwas evident in both the CD and mainly in UC populations. These findings are consistent with observations from clinical trials, and from real word experience too. The improved safety profile, novel mechanism of action and clinical need for new therapies has led to the rapid adoptionof vedolizumab use in clinical practice.

Keywords: vedolizumab, Crohn’s disease, ulcerative colitis, biologic therapy

Received: August 6, 2018; Accepted: September 10, 2018; Published: December 15, 2018  Show citation

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Douda T. Vedolizumab, its pharmacological profile and therapeutic use. Praktické lékárenství. 2018;14(E-verze 4/18):.
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