Prakt. Lékáren. 2018; 14(4e) [Psychiatr. praxi 2018; 19(2): 58-63]

Pharmacotherapy of Alzheimer disease and neuropsychiatric symptoms of dementia

Iva Prokopová
Oddělení klinické farmacie, Ústavní lékárna IKEM, Praha

Alzheimer disease is the most prevalent type of dementia. A precise diagnosis is required for effective management. Cholinesterase inhibitorsare used as first line therapy to provide modest symptomatic benefit in some patients, memantine appears to have modest benefits in patients with moderate to severe disease. Neuropsychiatric symptoms are common in dementia and contribute to nursing home admissionand caregiver stress. Identifying the genesis of the abnormal behavior is critical, in order that nonpharmacologic therapies are preferred overmedication. Symptomatic pharmacologic treatment includes antidepressants, antipsychotics, anxiolytics and other alternatives. The followingreview discusses risks and benefits of particular drugs.

Keywords: Alzheimer, demention, cholinesterase inhibitors, memantine, antidepressants, antipsychotics

Published: December 15, 2018  Show citation

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Prokopová I. Pharmacotherapy of Alzheimer disease and neuropsychiatric symptoms of dementia. Praktické lékárenství. 2018;14(E-verze 4/18):.
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