Prakt. lékáren. 2019; 15(1): 43-44 | DOI: 10.36290/lek.2019.008
Efficacy of topical nonsteroidal anti‑inflammatory drugs
- Ústav technologie léků, Farmaceutická fakulta, Veterinární a farmaceutická univerzita, Brno
Drugs from topical formulations should be able to penetrate into the skin and target areas in sufficient amounts to achieve a therapeutic effect. Factors influencing the ability of the topical drug to penetrate optimally into the skin and subcutaneous layers include the drug molecule size, its solubility in aqueous and lipophilic media, protein binding, acidity, the presence of the permeation enhancer in the topical formulation, and the type of medical form and its application. By analyzing randomized, blinded clinical studies, it was found that the best clinical effect was obtained after diclofenac administration in the form of emulgel. Diclofenac is a small, acidic, lipophilic and high protein binding molecule. Gels lack fatty bases and provide better drug release into skin compared to other systems for topical delivery of non-steroidal anti-inflammatory drugs. Additionally, in the emulgel form, diclofenac is concentrated in lipid droplets of the gel and the medical form has an even greater tendency to release the drug into the organism.
Keywords: non-steroidal anti-inflammatory drugs, topical application, permeation factors, emulgel, diclofenac
Published: March 15, 2019 Show citation
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