Prakt. Lékáren. 2019; 15(1e): 15-35 [Med. praxi. 2018;15(5):267-275]

Drug-drug interactions of warfarin and new direct oral anticoagulans

Michal Prokeš, Josef Suchopár
DrugAgency, a.s., Praha

Anticoagulation therapy with warfarin and direct oral anticoagulants annually saves lives of many patients. These patients often take medicines
that change the effect of anticoagulants. This article attempts to present in a synopical way information about such interactions that physicians
prescribe. Although warfarin has more interactions than DOAC, some DOAC interactions are equally dangerous and, unlike warfarin, the
effect of DOAC cannot be easily monitored. This may be a problem because there are patients in whom the drug interaction is more intense than in average patients, for example when dabigatran is combined with clarithromycin.

Keywords: drug-drug interactions, warfarin, NOAC, DOAC, clarithromycin

Published: March 15, 2019  Show citation

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Prokeš M, Suchopár J. Drug-drug interactions of warfarin and new direct oral anticoagulans. Pharmacy for Practice. 2019;15(E-verze 1/19):15-35.
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