Prakt. lékáren. 2021; 17(3): 147-149 | DOI: 10.36290/lek.2021.030

Drug induced gynecomastia

Daniel Bobek, Martin Šíma, Ondřej Slanař
Farmakologický ústav, 1. lékařská fakulta Univerzity Karlovy a Všeobecná fakultní nemocnice v Praze

Gynecomastia is a common finding in a male population. Regarding the literature we can estimate that approximately 3-16 % of male population has drug induced gynecomastia. Drugs are causing gynecomastia by variety of mechanisms, some of them are yet to be found. It is not surprising that among hormonal medications there are plenty of drugs with gynecomastia as an adverse effect. Other well-known drugs which can induce gynecomastia are spironolactone, omeprazole, some calcium channel blockers, some antiretroviral drugs, some antipsychotics, ethanol and alkylating agents. There are also lot of drugs which are speculated to cause a gynecomastia, however there is not enough evidence to support it.

Keywords: gynecomastia, adverse effect, hormonal therapy, spironolactone.

Published: October 12, 2021  Show citation

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Bobek D, Šíma M, Slanař O. Drug induced gynecomastia. Praktické lékárenství. 2021;17(3):147-149. doi: 10.36290/lek.2021.030.
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    References

    1. Dickson G. Gynecomastia. Am Fam Physician. 2012; 85(7): 716-722. Go to PubMed...
    2. Baumann K. Gynecomastia - Conservative and Surgical Management. Breast Care (Basel). 2018; 13(6): 419-424. Go to original source... Go to PubMed...
    3. Nuttall FQ, Warrier RS, Gannon MC. Gynecomastia and drugs: a critical evaluation of the literature. Eur J Clin Pharmacol. 2015; 71(5): 569-578. Go to original source... Go to PubMed...
    4. Eckman A, Dobs A. Drug-induced gynecomastia. Expert Opin Drug Saf. 2008; 7(6): 691-702. Go to original source... Go to PubMed...
    5. Bowman JD, Kim H, Bustamante JJ. Drug-induced gynecomastia. Pharmacotherapy 2012; 32(12): 1123-1140. Go to original source... Go to PubMed...
    6. Heresová J, Vrzáňová M. Gynecomastia. Interní medicína pro praxi 2003(1): 6-9.
    7. Deepinder F, Braunstein GD. Drug-induced gynecomastia: an evidence-based review. Expert Opin Drug Saf. 2012; 11(5): 779-795. Go to original source... Go to PubMed...
    8. Goldman RD. Drug-induced gynecomastia in children and adolescents. Can Fam Physician. 2010; 56(4): 344-345. Go to PubMed...
    9. Sansone A, Romanelli F, Sansone M, Lenzi A, Di Luigi L. Gynecomastia and hormones. Endocrine. 2017; 55(1): 37-44. Go to original source... Go to PubMed...
    10. Yazdani N, Matthews Branch S. Daily subcutaneous testosterone for management of testosterone deficiency. Front Biosci (Elite Ed). 2018; 10: 334-343. Go to original source... Go to PubMed...
    11. European database of suspected adverse drug reaction reports [online]. Dostupný na WWW: http://www.adrreports.eu/en/search_subst.html# [cit. 2021-05-05].

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