Prakt. lékáren. 2021; 17(3): e44-e52 | DOI: 10.36290/lek.2021.044

Curcumin - what we already know and what is promising

Helena Nejezchlebová, Tereza Svěchotová, Soňa Ševelová, Monika Dušková, Alena Žákovská
Přírodovědecká fakulta MU, Ústav experimentální biologie

Curcumin and its related compounds in the rhizome of the turmeric plant (Curcuma longa L.) bring multiple benefits for the organism. Anti-inflammatory and antioxidant properties of curcumin are considered to be the most important. There are reports confirming the preventive and ameliorating effects of this substance against different adverse health complications. Studies with focus on the management of the covid-19 disease also raise hope. However, curcumin is still contraindicated in pregnant women. New formulations that improve the bioavailability of this substance further enhance the potential of curcumin.

Keywords: Curcuma longa L., curcumin, pregnancy, covid-19.

Published: October 12, 2021  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Nejezchlebová H, Svěchotová T, Ševelová S, Dušková M, Žákovská A. Curcumin - what we already know and what is promising. Praktické lékárenství. 2021;17(3):e44-52. doi: 10.36290/lek.2021.044.
Download citation

References

  1. Opletal L. Přírodní látky a jejich biologická aktivita. Nutraceutika: primární metabolity a látky obsažené ve strukturovaných biologických systémech. Praha: Karolinum 2010: 378 s.
  2. Evropská agentura pro léčivé přípravky. Curcumae longae rhizoma. Dostupné na: https://www.ema.europa.eu/en/medicines/herbal/curcumae-longae-rhizoma (citováno 20. 7. 2021).
  3. Li S, Yuan W, Deng G, Wang P, Yang P, Aggarwal BB. Chemical composition and product quality control of turmeric (Curcuma longa L.). Pharmaceutical Crops 2011; 2(1): 28-54. Go to original source...
  4. Hewlings SJ, Kalman DS. Curcumin: A Review of Its' Effects on Human Health. Foods 2017; 6(10). Go to original source... Go to PubMed...
  5. Filardi T, Vari R, Ferretti E, Zicari A, Morano S, Santangelo C. Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications? Nutrients 2020; 12(10). Go to original source... Go to PubMed...
  6. Hosseini A, Hosseinzadeh H. Antidotal or protective effects of Curcuma longa (turmeric) and its active ingredient, curcumin, against natural and chemical toxicities: A review. Biomedicine 2018; 99: 411-421. Go to original source... Go to PubMed...
  7. Opletal L. Přírodní látky a jejich biologická aktivita. Nutraceutika: sekundární metabolity rostlin. Praha: Karolinum 2016: 698 s.
  8. Petrohilos S. Curcumin and depression: A literature review. Journal of the Australian - Traditional Medicine Society 2017; 23(2): 88-93. Go to original source...
  9. Ghaneifar Z, Yousefi Z, Tajik F, Nikfar B, Ghalibafan F, Abdollahi E a Momtazi-Borojeni AB. The potential therapeutic effects of curcumin on pregnancy complications: Novel insights into reproductive medicine. IUBMB Life 2020; 72(12): 2572-2583. Go to original source... Go to PubMed...
  10. Pasparakis M. Regulation of tissue homeostasis by NF-κB signalling: Implications for inflammatory diseases. Nature Reviews Immunology 2009; 9: 778-788. Go to original source... Go to PubMed...
  11. Tossetta G, Fantone S, Giannubilo SR, Marzioni D. The Multifaced Actions of Curcumin in Pregnancy Outcome. Antioxidants (Basel) 2021; 10(1): 126. Go to original source... Go to PubMed...
  12. Babaei F, Nassiri-Asl M, Hosseinzadeh H. Curcumin (a constituent of turmeric): New treatment option against COVID-19. Food Science & Nutrition 2020; 8(10): 5215-5227. Go to original source... Go to PubMed...
  13. Gupta H, Gupta M, Bhargava S. Potential use of turmeric in COVID-19. Clinical and Experimental Dermatology 2020; 45(7): 902-903. Go to original source... Go to PubMed...
  14. Rocha FAC, Assis MR. Curcumin as a potential treatment for COVID-19. Phytotherapy Research 2020; 34(9): 2085-2087. Go to original source... Go to PubMed...
  15. Soni VK, Mehta A, Ratre YK, Tiwari AK, Amit A, Singh RP, Sonkar SC, Chaturvedi N, Shukla D, Vishvakarma NK. Curcumin, a traditional spice component, can hold the promise against COVID-19? European Journal of Pharmacology 2020; 886: 173551. Go to original source... Go to PubMed...
  16. Rattis BAC, Ramos SG, Celes MRN. Curcumin as a Potential Treatment for COVID-19. Frontiers in Pharmacology 2021; 12: 675287. Go to original source... Go to PubMed...
  17. Thimmulappa RK, Mudnakudu-Nagaraju KK, Shivamallu C, Subramaniam KJT, Radhakrishnan A, Bhojraj S, Kuppusamy G. Antiviral and immunomodulatory activity of curcumin: A case for prophylactic therapy for COVID-19. Heliyon 2021; 7(2): e06350. Go to original source... Go to PubMed...
  18. Kunnumakkara AB, Bordoloi D, Padmavathi G, Monisha J, Roy NK, Prasad S, Aggarwal BB. Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. British Journal of Pharmacology 2017;174(11): 1325-1348. Go to original source... Go to PubMed...
  19. Evropská agentura pro léčivé přípravky. European Union herbal monograph on Curcuma longa L., rhizoma. Dostupné na: https://www.ema.europa.eu/en/documents/herbal-monograph/final-european-union-herbal-monograph-curcuma-longa-l-rhizoma-revision-1_en.pdf (citováno 20. 7. 2021)
  20. Anand P, Sundaram C, Jhurani S, Kunnumakkara AB, Aggarwal BB. Curcumin and cancer: an "old-age" disease with an "age-old" solution. Cancer Letters 2008; 267: 133-164. Go to original source... Go to PubMed...
  21. Rasyid A, Rahman ARA, Jaalam K, Lelo A. Effect of different curcumin dosages on human gall bladder. Asia Pacific journal of clinical nutrition 2002; 11: 314-318. Go to original source... Go to PubMed...




Pharmacy for Practice

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.