Prakt. lékáren. 2022; 18(3): e12-e23 [Neurol. praxi. 2022;23(1):76-83]

Analgesics in neurology, their specific fealures and adverse effects

Dana Halbichová
Centrum bolesti VFN Praha, KARIM a neurologická ambulance, Praha

Each one of us has a lot of experience with pain management and painkillers, both professional and personal. The goal of this article is therefore to only point out what the specifics, advantages, risks and interactions of the representatives of individual groups are. It is not possible to encompass a complete summary of those - some of them are even not registered in the Czech Republic (flupirtine, nefopam) for pain management. In our country, methadon is a newly approved drug for the treatment of severe pain which cannot be influenced by non-narcotic painkillers. Co-analgetics are mentioned only peripherally, despite the fact that they are an inseparable part of neuropatic and chronic pain treatment. A more detailed discussion of their effect would probably make for a new article. Therapy depends on the type and nature of pain; we choose a different one with chronic, acute, neuropathic or oncologic pain. Chronic pain is more frequent in women and increases rapidly with ages 65 and more.

Keywords: painkillers, chronic pain, inetrakctions, adverse effects.

Published: October 27, 2022  Show citation

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Halbichová D. Analgesics in neurology, their specific fealures and adverse effects. Praktické lékárenství. 2022;18(3):e12-23.
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References

  1. Adam Z. Neopioidní analgetika - farmakologie a léčebné využití. (Cit. 11. 9. 21). Dostupné na: https://zdravi.euro.cz/clanek/postgradualni-medicina/neopioidni-analgetika-farmakologie-a-lecebne-vyuziti-173267.
  2. Baltus J. Farmakokinetika, účinek léku a lékové interakce. Remedia. 2015;2:115-119.
  3. Booting R. Ayoub S. COX-3 and the mechanism of action paracetamol/acetaminophen. Review Prostaglandins leukot Essent Fatty Acids. 2005;72(2):85-87. Go to original source... Go to PubMed...
  4. Burn J. Aspirin může chránit před rakovinou tlustého střeva a konečníku. Prezentováno na 21. 9. 2009 na 34 kongresu European Society for medical oncology. Dostupné z www: https://www.onconet.cz/index.php?pg=aktuality&aid=401.
  5. Dahlhamer J, Lucas J, Zelaya C. Prevalence of Chronic Pain and High-Impact Chronic Pain Among Adults - United States, 2016. MMWR Morb Mortal Wkly Rep. 2018;67:1001-1006. Go to original source... Go to PubMed...
  6. De Luca G. Představujeme molekulu, role glutathionu v klinické praxi. (Cit 11. 9. 2021). Dostupné na: http://www.edukafarm.cz/data/soubory//casopisy/BIOTHERAPEUTICS%202-2016/8.pdf.
  7. Danyi P. Lékové interakce v revmatologii. Dostupné z www: https://zdravi.euro.cz/clanek/postgradualni-medicina/lekove-interakce-v-revmatologii-484087, navštíveno 18. 9. 2021.
  8. De Luca G. Představujeme molekulu, role glutathionu v klinické praxi. (Cit. 11. 9. 2021). Dostupné na: http://www.edukafarm.cz/data/soubory//casopisy/BIOTHERAPEUTICS%202-2016/8.pdf.
  9. Dítě P, Zbořil V, Novotný I. Gastrointestinální komplikace při užívání nesteroidních antirevmatik. Interní med. 2002;4:168-170.
  10. Doseděl M. Nežádoucí účinky a lékové interakce nesteroidních antiflogistik a jejich management pohledem farmaceuta. Praktické lek. 2014;10:90-94.
  11. Freo U, Ruocco Ch, Valerio A, et al. Parcetamol: Areview of Guideline Recommendations. J Clin Med. 2021;10(15):3420. Go to original source... Go to PubMed...
  12. Hersley LA, Lipton BR. Naproxen for presymptomatic Alzheimer disease, is this the end, or shall we try again? (Cit. 5. 4. 2019). Dostupné na: https://doi.org/10.1212/WNL.0000000000007233. Go to original source... Go to PubMed...
  13. Juřica J. Kyselina acetylosalicylová - galenické faktory ovlivňující antiagregační účinek. Remedia. 2017;4:377-382.
  14. Khuen Lee T, Stupans I, Peek RM. Radioprotection: the non-steroidal anti-inflammatory drugs (NSAIDs) and prostaglandins, Review J Pharm Pharmacol. 2002;54(11):1435-1445. Go to original source... Go to PubMed...
  15. Koxiby. (Cit. 21. 8. 2021). Dostupné na: https://www.akutne.cz/res/publikace/koxiby-2019.
  16. Koxiby a riziko gastrointestinálních a kardiálních komplikací. (Cit. 21. 8. 2021). Dostupné na: https://www.sukl.cz/koxiby-a-riziko-gastrointestinalnich-kardiovaskularnich-a.
  17. Kozák J, Lejčko J, Vrba I. Opioidy. Praha: Maxdorf 2021:96-99s.ISBN: 978-80-7345-664-1.
  18. Léčba bolesti. (Cit. 10. 6. 2021). Dostupné na: https://www.prolekare.cz/kreditovane-kurzy/lecba-bolesti-45/lecba_bolesti-42.
  19. Lejčko J. Přehled opioidních analgetik. Praktické lek. 2009;5(4):172-175.
  20. Lejčko J, Kozák J, Fricová J, et al. Metodické pokyny pro farmakoterapii bolesti. Bolest 2016;19(suppl. 1).
  21. List of the names, pharmaceutical of the names, pharmaceutical forms, strenghts of the medicinal products, route of administration, marketing authorisation holders in the member states and Norway and Iceland. (Cit. 20. 8. 2021). Dostupné na: www.emea.europa.eu.
  22. Maślanka T, Jasiecka-Mikołajczyk A, Jaroszewski JJ. Pharmacological characteristics of metamizole. Polish Journal of Veterinary Sciences. 2014. doi: 10.2478/pjvs-2014-0030. Source: PubMed. Go to original source...
  23. Metadon alkaloid 10 mg/ml, perorální roztok. (Cit 15. 11. 2021). Dostupné z www: https://mediately.co/cz/drugs/6T6QDKUsWaTmGOscbK1iVeyMPlr/metadon-alkaloid-10mg-ml-peroralni-kapky-roztok.
  24. Milijana N, Miljković X, Nemanja K, et al. Metamizole: Current Status of the Safety and Efficacy. Hospital Pharmacology. 2018;5(3):694-704. Go to original source...
  25. Miotto K, Cho A, Khalil A, et al. Trends in Tramadol: Pharmacology, metabolism and Misue. Review. Anesth Analg. 2017;124(1):44-51. Go to original source... Go to PubMed...
  26. Nežádal T. Nesteroidní antirevmatika v léčbě akutní bolesti z pohledu neurologa. Med. Praxi. 2017;14(3):142-146. Go to original source...
  27. Nosková P. Fixní kombinace paracetamolu a tramadolu v praxi. Neurol. praxi. 2020;21(1):68-71. Go to original source...
  28. Oral I. Léky snižující účinnost antihypertenziv. Klin Farmakol Farm. 2004;18:22-2.
  29. Pavelka K, Olejárová M. Nesteroidní antiflogistika. Compendium - léčiva používaná v podmínkách ČR. Praha: Panax 2018; Co 2018:837-852.
  30. Peek R. Prevention of colorectal cancer through the use of COX-2 selective inhibitors. Review Cancer Chemother Pharmacol. 2004;54(1):S50-56. Go to original source... Go to PubMed...
  31. Prokeš M, Suchopár J. Serotoninový syndrom: co bychom o něm měli vědět. Med. praxi. 2014;1(5):226-230.
  32. Rokyta R, Kršiak M, Doležal T, Lejčko J. Neopioidní analgetika. Bolest. Praha: Tigis 2012:116-126.
  33. Šimíček M. Oxfordská liga analgetik a terapie akutní bolesti z pohledu farmaceuta. Praktické lék. 2014;10(5):166-170.
  34. Suchý D, Reichl M. Moderní nesteroidní antirevmatika: klady a zápory. Klin Farmakol Farm. 2003;17:166-169.
  35. Vlad CS, Miller DR, Kowall NW, et al. Protective effects of NSAIDs on the development of Alzheimer disease. 2008. Go to original source...




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