New options in the treatment of hypercholesterolaemia

Vladimír Soška, Ondřej Kyselák

Prakt. Lékáren. 2016; 12(4e)  

Statins are the key drugs for LDL-cholesterol lowering: they have a lot of evidences that they decrease not only cholesterol, but also cardiovascularevents and mortality. Second-line choice for lowering LDL-cholesterol is ezetimibe, which is intended to combination with statins.This year were published results of IMPROVE-IT study which showed that addition of ezetimibe to statin has also clinical benefit – decrease ofcardiovascular events. New lipid-lowering drugs are PCSK9-inhibitors, first two of which were already approved for clinical use.

Combination therapy of arterial hypertension – a review of actual guidelines

Barbora Nussbaumerová

Prakt. Lékáren. 2016; 12(4e)  

The article summarizes the present oppinion on the combination treatment of arterial hypertension. The most recommended and evidencebased combinations are 1/angiotensin converting enzyme inhibitor/angiotensin receptor blocker + calcium channel blocker, 2/ angiotensinconverting enzyme inhibitor/angiotensin receptor blocker + diuretic and 3/ calcium channel blocker + diuretic. Fixed combination of 2 or 3drugs are available and recommended.

New ways of administering injection drugs in relapsing multiple sclerosis

Jiří Piťha

Prakt. Lékáren. 2016; 12(4e)  

The review article provides information on new ways of administering parenteral drugs indicated in the treatment of multiple sclerosis orclinically isolated syndrome. The issues covered include reducing the frequency of administration and increasing the dose, switching fromintravenous or intramuscular to subcutaneous administration, or altering the active molecule. The new drugs have the same efficacy as theoriginal ones, while the rate of adverse effects is maintained or even reduced.

Mucoadhesive buccal films – a modern dosage form

Jan Gajdziok

Prakt. Lékáren. 2016; 12(4e): e20-e26 | DOI: 10.36290/lek.2016.083  

This article aims to provide an overview about mucoadhesive dosage forms applied to the oral cavity, focusing on the innovative formulationsof mucoadhesive films in terms of their advantages, composition, preparation and practical use. Films (patches) composed of mucoadhesivepolymers prepared by any of the established methods (solvent casting, melt-extrusion, etc.) may be promising candidates for oral administrationof many drugs, especially for their flexibility and convenience of use. Other advantages of these formulations include prolongation ofa short retention time of conventional oral dosage forms to the mucosa and administration of precise doses...

K vývoji naší farmaceutické historiografie

Prakt. Lékáren. 2016; 12(4e): e27-e34  

E-verze 4/16

Prakt. Lékáren. 2016; 12(4e)