Prakt. lékáren. 2007; 3(2): 72-74

Přírodní látky v léčbě a prevenci alkoholizmu

Mgr. Jan Martin Ph.D, doc. RNDr. Jaroslav Dušek CSc
Katedra farmakognosie, FaF v Hradci Králové

Alkoholizmus je jedna z nejzávažnějších a nejrozšířenějších forem závislosti. Jeho terapie je velmi problematická a dlouhodobá. Z posledních výzkumů přírodních léčiv vyplývá, že látky z některých rostlin mohou snižovat dobrovolný příjem alkoholu nebo zmírňovat abstinenční příznaky. Mezi nejperspektivnější přírodní látky s těmito účinky patří deriváty alkaloidu ibogainu, isoflavonoidy puerarin a daidzin a floroglucinový derivát hyperforin.

Keywords: alkohol, alkoholizmus, Tabernanthe iboga, Pueraria lobata, Hypericum perforatum, třezalka, Panax ginseng, Salvia miltiorrhiza

Published: May 1, 2007  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Martin J, Dušek J. Přírodní látky v léčbě a prevenci alkoholizmu. Praktické lékárenství. 2007;3(2):72-74.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Colombo G, Agabio R, Lobina C. Salvia miltiorrhiza Extract Inhibits Alcohol Absorption, Preference, and Discrimination in sP Rats. Alcohol 1999; 18: 65-70. Go to original source... Go to PubMed...
    2. De Vry J, Maurel S, Screiber R, et al. Comparison of Hypericum extracts with imipramine and fluoxetine in animal models of depression and alcoholism. Eur. Neuropsychopharm. 1999; 9: 461-468. Go to original source... Go to PubMed...
    3. Glick SD, Kuehne ME, Raucci J, et al. Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum. Brain Res. 1994; 657: 14-22. Go to original source... Go to PubMed...
    4. Höschl C. Teorie deprese. Psychiatrie 1998; 2: 78-85.
    5. Kasper S. Hypericum perforatum - a Review of Clinical Studies. Pharmacopsychiatry 2001; 34: 51-55. Go to original source... Go to PubMed...
    6. Keung WM, Vallee BL. Daidzin and daidzein suppress free-choice alcohol intake by Syrian golden hamsters. Proc. Natl. Acad. Sci. USA 1993; 90: 10008-10012. Go to original source... Go to PubMed...
    7. Keung WM, Vallee BL. Kudzu root: an ancient chinese source of modern antidipsotropic agents. Phytochemistry 1998; 47: 499-506. Go to original source... Go to PubMed...
    8. Layer RT, Skolnick P, Bertha CM, et al. Structurally modified ibogaine analogs exhibit differing affinities for NMDA receptors. Eur. J. Pharmacol. 1996; 309: 159-165. Go to original source... Go to PubMed...
    9. Lee YJ, Pantuck CB, Pantuck EJ. Effect of Ginseng on Plasma Levels of Ethanol in the Rat. Planta Med. 1993; 59: 17-19. Go to original source... Go to PubMed...
    10. Lee YW, Cook CE, Fang Y, et al. Application of analytical high-speed countercurrent chromatography to the isolation of bioactive natural products. J. Chromatogr. A 1989; 477: 434-438. Go to original source... Go to PubMed...
    11. O'Hearn E, Molliver ME. Degeneration of purkinje cells in parasagittal zones of the cerebellar vermis after treatment with ibogaine or harmaline. Neuroscience 1993; 53: 303-310. Go to original source... Go to PubMed...
    12. Paškulin R, Jamnik P, Živin M, et al. Ibogaine affects brain energy metabolism. Eur. J. Pharmacol. 2006; 552: 11-14. Go to original source... Go to PubMed...
    13. Persson H. Mushrooms. Medicine 2003; 31: 61-63. Go to original source...
    14. Rezvani AH, Overstreet DH, Lee YW. Attenuation of alcohol intake by ibogaine in three stains of alcohol preferring rats. Pharmacol. Biochem. Behav. 1995; 52: 615-620. Go to original source... Go to PubMed...
    15. Rezvani AH, Overstreet DH, Perfumi M, et al. Plant derivatives in the treatment of alcohol dependency. Pharmacol. Biochem. Behav. 2003; 75: 593-606. Go to original source... Go to PubMed...
    16. Rezvani AH, Overstreet DH, Yang Y, et al. Attenuation of Alcohol Consumption by a Novel Nontoxic Ibogaine Analogue (18-Methoxycoronaridine) in Alcohol-Preferring Rats. Pharmacol. Biochem. Behav. 1997; 58: 615-619. Go to original source... Go to PubMed...
    17. Rezvani AH, Overstreet DH, Yang Y, et al. Attenuation of alcohol intake by the extract of Hypericum perforatum (St John's Wort) in two different strains of alcohol preferring rats. Alcohol Alcohol. 1999; 34: 699-705. Go to original source... Go to PubMed...
    18. Wiseman JS, Abeles RH. Mechanism of inhibition of aldehyde dehydrogenase by cyclopropanone hydrate and the mushroom toxin coprine. Biochemistry 1979; 18: 427-435. Go to original source... Go to PubMed...
    19. Xie CI, Lin RC, Antony V, et al. Daidzin an antioxidant isoflavonoid decreases blood alcohol levels and shortens sleep time induced by alcohol intoxication. Alcohol. Clin. Exp. Res. 1994; 18: 1443-1448. Go to original source... Go to PubMed...

    Return to the content


    Pharmacy for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.