Prakt. lékáren. 2011; 7(2): 80-84

Vulvovaginal candidiasis, pharmacotherapy and prevention

PharmDr.Petr Horák
Nemocniční lékárna FN Motol a Katedra lékárenství IPVZ, Praha

Vulvovaginal candidiasis is one of the most common fungal diseases. Approximately 75 % of women will have experienced at least one

episode of this disease during their life. The sporadic form of vulvovaginal candidiasis can be treated very successfully with topical or

systemic azole antifungals in short or unit-dose regimens. Special care has to be devoted to therapy of pregnant women and complicated

and recurrent forms of the disease. Self-medication is often involved in the therapy of vulvovaginal candidiasis; correct consultation

from the pharmacist plays an important role then.

Keywords: vulvovaginal candidiasis, azole antifungals, yeasts

Published: April 5, 2011  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Horák P. Vulvovaginal candidiasis, pharmacotherapy and prevention. Praktické lékárenství. 2011;7(2):80-84.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Helms RA, Quan DJ, Herfindal ET, Gourley DR. Textbook of Therapeutics. Drug and Disease Management. 8th Edition. Philadelphia: Lippincott Williams & Wilkins 2006; 2780 s.
    2. Sobel JD, Faro S, Force RW, Foxman B, Ledger WJ, Nyirjesy PR, Reed BD, Summers P. Vulvovaginal candidiasis: Epidemiologic, diagnostic, and therapeutic considerations. Am. J Obstet Gynecol 1998; 178(2): 203-211. Go to original source... Go to PubMed...
    3. Nabhan A. Vulvovaginal Candidiasis. Ain Shams Journal Of Obstetrics And Gynecology 2006; 3(2): 73-79.
    4. Sobel JD. Genital Candidiasis. Medicíně 2010; 38(6): 286-290. Go to original source...
    5. Mašata J, Jedličková A. Přehled nejčastějších vulvovaginálních infekcí. Praktická gynekologie 2002; 2: 31-38.
    6. Špaček J, Buchta V, Jílek P, Förstl M. Clinical aspects and luteal phase assessment in patients with recurrent vulvovaginal candidiasis. European Journal of Obstetrics & Gynecology and Reproductive Biology 2007; 131: 198-202. Go to original source... Go to PubMed...
    7. Ventolini G, Baggish MS. Recurrent Vulvovaginal Candidiasis. Clinical Microbiology Newsletter 2006; 28(12): 93-95. Go to original source...
    8. Spinillo A, Capuzzo E, Acciano S, De Santolo A, Zara F. Effect of antibiotic use on the prevalence of symptomatic vulvovaginal candidiasis. Am J Obstet Gynecol 1998; 180(1): 14-17. Go to original source... Go to PubMed...
    9. Farage M, Bramante M, Otaka Y, Sobel J. Do panty liners promote vulvovaginal candidiasis or urinary tract infections? A review of the scientific evidence. European Journal of Obstetrics & Gynecology and Reproductive Biology 2007; 132: 8-19. Go to original source... Go to PubMed...
    10. Tarry W, Fisher M, Shen S, Mawhinney M. Candida Albicans: The Estrogen Target for Vaginal Colonization. Journal of Surgical Research 2005; 129: 278-282. Go to original source... Go to PubMed...
    11. Chassota F, Negri MFN, Svidzinski AE, Donatti L, Peralta RM, Svidzinski TIE, Consolaro MEL. Can intrauterine contraceptive devices be a Candida albicans reservoir? Contraception 2007; 77: 355-359. Go to original source... Go to PubMed...
    12. Douglas LC, Sanders ME. Probiotics and Prebiotics in Dietetics Practice. Journal of the American Dietetic Association 2008; 108(3): 510-521. Go to original source... Go to PubMed...
    13. Ya W, Reifer C, Miller LE. Efficacy of vaginal probiotic capsules for recurrent bacterial vaginosis: a double-blind, randomized, placebo-controlled study. American Journal of Obstetrics & Gynecology 2010; 120: e2-e6. Go to original source... Go to PubMed...
    14. Ehrström S, Daroczy K, Rylander E, Samuelsson C, Johannesson U, Anzén B, P?hlson C. Lactic acid bacteria colonization and clinical outcome after probiotic supplementation in conventionally treated bacterial vaginosis and vulvovaginal candidiasis. Microbes and Infection 2010; 12: 691-699. Go to original source... Go to PubMed...
    15. Hay P, Ugwumadu A. Detecting and treating common sexually transmitted disease. Best Practice & Research Clinical Obstetrics and Gynaecology 2009; 23: 647-660. Go to original source... Go to PubMed...
    16. Leikin JB, Paloucek FP. Poisoning & Toxicology Handbook, 3rd Edition. Hudson: Lexi-Comp, 2002; 1553 s.
    17. Bachmann KA, Lewis JD, Fuller MA, Bonfiglio MF. Drug Interactions Handbook, 2nd Edition. Hudson: Lexi-Comp, 2004: 789 s.
    18. Hisaka A, Ohno Y, Yamamoto T, Suzuki H. Prediction of pharmacokinetic drug-drug interaction caused by changes in cytochrome P450 activity using in vivo information. Pharmacology & Therapeutics 2010; 125: 230-248. Go to original source... Go to PubMed...
    19. Pitsouni E, Iavazzo C, Falagas ME. Itraconazole vs. fluconazole for the treatment of uncomplicated acute vaginal and vulvovaginal candidiasis in nonpregnant women: a metaanalysis of randomized controlled trials. American Journal of Obstetrics & Gynecology 2008; 153-160. Go to original source... Go to PubMed...
    20. Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 7th Edition. Philadelphia: Lippincott Williams & Wilkins, 2005. 1858 s.
    21. Databáze léčiv Státního ústavu pro kontrolu léčiv. (Online) (cit. 25. 2. 2011). Dostupné na http://www.sukl.cz/modules/medication/search.php?data(search_for)=&data(code)=&data(atc_group)=G01&data(material)=&data(path)=&data(reg)=&data(radio)=none&data(chbox)()=marketability&data(rc)=&data(with_adv)=0&search=Vyhledat&data(listing)=20.
    22. Cotch MF, Hillier SL, Gibbs RS, Eschenbach DA. Epidemiology and outcomes associated with moderate to heavy Candida colonization during pregnancy. Am J Obstet Gynecol 1998; 178(2): 374-380. Go to original source... Go to PubMed...
    23. Torgerson RR, Marnach ML, Bruce AJ, Rogers RS. Oral and vulvar changes in pregnancy. Clinics in Dermatology 2006; 24: 122-132. Go to original source... Go to PubMed...
    24. Sobel JD. Vulvovaginal candidosis. Lancet 2007; 369: 1961-1971. Go to original source... Go to PubMed...
    25. Ventolini G, Baggish MS. Post-menopausal recurrent vaginal candidiasis: effect of hysterectomy on response to treatment, type of colonization and recurrence rates post-treatment. Maturitas 2005; 51: 294-298. Go to original source... Go to PubMed...
    26. Sobel JD, Wiesenfeld HC, Martens M, Danna P, Hooton TM, Rompalo A, Sperling M, Livengood C, Horowitz B, Von Thron J, Edwards L, Panzer H, Chu TC. Weekly doses of fluconazole prevented recurrence of vulvovaginal candidiasis. Evidencebased Obstetrics and Gynecology 2005; 7: 76-77.
    27. Shahid Z, Sobel JD. Reduced fluconazole susceptibility of Candida albicans isolates in women with recurrent vulvovaginal candidiasis: effects of long-term fluconazole therapy. Diagnostic Microbiology and Infectious Disease 2009; 64: 354-356. Go to original source... Go to PubMed...
    28. Donders G, Bellen G, Byttebier G, Verguts L, Hinoul P, Walckiers R, Stalpaert M, Vereecken A, Van Eldere J. Individualized decreasing-dose maintenance fluconazole regimen for recurrent vulvovaginal candidiasis (ReCiDiF trial). American Journal of Obstetrics & Gynecology 2008; 613: e1-e9. Go to original source... Go to PubMed...
    29. Guaschino S, De Seta F, Sartore A, Ricci G, De Santo D, Piccoli M, Alberico S. Efficacy of maintenance therapy with topical boric acid in comparison with oral itraconazole in the treatment of recurrent vulvovaginal candidiasis. American Journal of Obstetrics and Gynecology 2001; 184: 598-602. Go to original source... Go to PubMed...
    30. Phillips AJ. Treatment of non-albicans Candida vaginitis with amphotericin B vaginal suppositories. American Journal of Obstetrics and Gynecology 2005; 192: 2009-2013. Go to original source... Go to PubMed...
    31. Databáze léčiv Státního ústavu pro kontrolu léčiv. (Online) (cit. 25. 2. 2011). Dostupné na http://www.sukl.cz/modules/medication/search.php?data(search_for)=&data(code)=&data(atc_group)=G01&data(material)=&data(path)=&data(reg)=&data(radio)=no-recipe&data(chbox)()=marketability&data(rc)=&data(with_adv)=0&search=Vyhledat&data(listing)=20.

    Return to the content


    Pharmacy for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.