Prakt. Lékáren. 2015; 11(5e) [Klin Farmakol Farm. 2015;29(2):49-52]

Development of resistance of invasive bacteria related to antibiotic consumption

Milan Kolář1, Pavlína Štrbová2
1 Ústav mikrobiologie LF UP a FN Olomouc
2 Ústav klinické farmakologie LF UP a FN Olomouc

Increasing resistance of bacterial pathogens to antibiotic therapy represents a serious health problem. It is apparent that an integralpart of the sources of rational antibiotic therapy is surveillance of bacterial resistance. The present study aimed at analyzing the resistanceof invasive bacterial pathogens isolated from blood cultures with respect to consumption of antimicrobial agents. The obtainedresults suggest a worrying situation concerning the resistance of certain invasive bacteria to antimicrobial drugs. Despite reducedconsumption of third-generation cephalosporins and fluoroquinolones, the resistance of Klebsiella pneumoniae to these antibioticscontinues to rise. A direct association between increased consumption and bacterial resistance was noted in piperacillin/tazobactamand carbapenems. In the following period, surveillance of bacterial resistance and adherence to the principles of rational antibiotictherapy are necessary to slow down the pace of this negative trend.

Keywords: bacteria, blood cultures, resistance, antibiotics

Published: August 1, 2015  Show citation

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Kolář M, Štrbová P. Development of resistance of invasive bacteria related to antibiotic consumption. Praktické lékárenství. 2015;11(E-verze 5/15):.
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    References

    1. Luna CM, Vujacich P, Niederman MS, et al. Impact of BAL data on the therapy and outcome of ventilator-associated pneumonia. Chest 1997; 111: 676-685. Go to original source... Go to PubMed...
    2. Tumbarello M, Sanguinetti M, Montuori E, et al. Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-ß-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment. Antimicrob Agents Chemother 2007; 51: 1987-1994. Go to original source... Go to PubMed...
    3. Hanulík V, Uvízl R, Husičková V, Htoutou Sedláková M, Kolář M. Bakteriální původci pneumonií u pacientů v intenzivní péči. Klin Mikrobiol Inf Lék 2011; 17: 134-139.
    4. Rello J, Torres A, Ricart M, et al. Ventilator-associated pneumonia by Staphylococcus aureus. Comparison of methicillin-resistant and methicillin-sensitive episodes. Am J Respir Crit Care Med 1994; 150: 1545-1549. Go to original source... Go to PubMed...
    5. Kolář M, Htoutou Sedláková M, Šenkyříková M, Hanulík V, Honig P. Vliv rezistence Pseudomonas aeruginosa na antibioterapii. Klin Farmakol Farm 2013; 27: 101-105.
    6. European Antimicrobial Resistance Surveillance Network (EARS-Net). http://www.ecdc.europa.eu/en/healthtopics/antimicrobial_resistance/database/Pages/database.aspx.
    7. Kolar M, Urbanek K, Latal T. Antibiotic selective pressure and development of bacterial resistance. Int J Antimicrob Agents 2001; 17: 357-363. Go to original source... Go to PubMed...
    8. Urbánek K, Kolář M, Lovečková Y, Strojil J, Šantavá L. Influence of third-generation cephalosporin utilization on the occurrence of ESBL-positive Klebsiella pneumoniae strains. J Clin Pharm Therapeutics 2007; 32: 403-408. Go to original source... Go to PubMed...
    9. Haller P, Tschudin S, Dangel M. Increase of resistant Enterobacter isolates and correlation with antibiotic consumption at the ward level. Poster presented in 16. European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Nice, 2006. http://registration.akm.ch/einsicht.php?XNABSTRACT_ID=17620&XNSPRACHE_ID=2&XNKONGRESS_ID=26&XNMASKEN_ID=900.
    10. Htoutou Sedláková M, Vojtová V, Hanulík V, Suchánková H, Kolář M. Rezistence enterobakterií k vybraným antibiotikům v souvislosti s jejich spotřebou. Klin Farmakol Farm 2012; 26: 61-66.
    11. European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. http://www.eucast.org/clinical_breakpoints.
    12. Anatomical therapeutic chemical (ATC) index (including defined daily doses (DDDs) for plain substances) Oslo: WHO collaboration centre for drug statistics methodology, 1996.
    13. Global Risks 2013, Eighth Edition. World Economic Forum, http://www3.weforum.org/docs/WEF_GlobalRisks_Report_2013.pdf.
    14. Kolář M, Urbánek K, Hanulík V, Vojtová V. Vliv antibiotické léčby na vývoj bakteriální rezistence. Klin Farmakol Farm 2010; 24: 181-183.

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