Prakt. lékáren. 2018; 14(2): 67-69 | DOI: 10.36290/lek.2018.012

Therapeutic drug monitoring in clinical practice

Hana Suchánková^1,2

¹ Oddělení geriatrie, Fakultní nemocnice Olomouc

² Ústav farmakologie, Lékařská fakulta, Univerzita Palackého v Olomouci

To optimise patients’outcomes of pharmacotherapy, special attention should be given to dosing selection. Therapeutic drugmonitoring (TDM) is a dosing individualisation strategy that helps to minimise toxicity whilst maximising the efficacy of the agentand helps to reduce the health care costs. To optimise dosing, pharmacokinetic characteristics and pharmacodynamic target ofthe agent must be considered. The aim of this paper is to review the role of TDM in clinical practice, summarise characteristicsof drugs suitable for TDM and identify patients that would most likely benefit from it, outline limitations of methods used tomeasure drug concentrations, describe dosing adjustments strategies and finally discuss the concentration-effect relationshipand therapeutic targets of antimicrobials.

Keywords: TDM, pharmacokinetics, dosing regimen, concentration

Published: June 20, 2018  Show citation