Prakt. lékáren. 2022; 18(4): 214-218 | DOI: 10.36290/lek.2022.045

Treatment of lower urinary tract symptoms and erectile dysfunction

Marcela Čechová
Urologická klinika 2. LF UK a FN Motol, Praha

Lower urinary tract symptoms (LUTS) and erectile dysfunction (ED) represent most common male problems, typically associated with aging. Moreover, these problems are often combined and can have a negative impact on quality of life. LUTS have been typically related to subvesical obstruction due to prostatic hyperplasia (BPH), however can have several other causes. If treatment is required, LUTS/BPH can be managed in most cases pharmacologically. If surgical treatment is indicated, endoscopic approach is preferred. Effective pharmacological options are also available in the treatment of ED, the most used drugs are phosphodiesterase type 5 inhibitors. Another pharmacological option is topical, intraurethral or intracavernous application of a vasoactive agent, predominantly alprostadil. Penile prosthesis remains the last option. This text summarizes the current treatment options of these problems focused on pharmacotherapy, moreover on possible risks of concurrent treatment.

Keywords: lower urinary tract symptoms, LUTS, benign prostatic hyperplasia, erectile dysfunction, pharmacotherapy.

Accepted: December 1, 2022; Published: December 15, 2022  Show citation

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Čechová M. Treatment of lower urinary tract symptoms and erectile dysfunction. Praktické lékárenství. 2022;18(4):214-218. doi: 10.36290/lek.2022.045.
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References

  1. Cornu J­‑NL, Gravas S, Gacci M, et al. Management of Non­‑neurogenic Male LUTS. EAU Guidelines. Arnhem: EAU Guidelines Office; 2022. Available from: https://uroweb.org/guidelines/management­‑of­‑non­‑neurogenic­‑male­‑luts.
  2. Djavan B, Chapple C, Milani S, et al. State of the art on the efficacy and tolerability of alpha1-adrenoceptor antagonists in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia. Urology. 2004 Dec;64(6):1081-8. Go to original source... Go to PubMed...
  3. SPC jednotlivých léků, dostupné z Databáze léků. Státní ústav pro kontrolu léčiv [online], SÚKL: © 2010 [cit. 30. 8. 2022]. Available from: https://www.sukl.cz/.
  4. Roehrborn CG, Siami P, Barkin J, et al. CombAT Study Group. The effects of combination therapy with dutasteride and tamsulosin on clinical outcomes in men with symptomatic benign prostatic hyperplasia: 4-year results from the CombAT study. Eur Urol. 2010 Jan;57(1):123-31. Go to original source... Go to PubMed...
  5. McConnell JD, Roehrborn CG, Bautista OM, et al. Medical Therapy of Prostatic Symptoms (MTOPS) Research Group. The long­‑term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia. N Engl J Med. 2003 Dec 18;349(25):2387-98. Go to original source... Go to PubMed...
  6. Feldman HA, Goldstein I, Hatzichristou DG, et al. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol. 1994 Jan;151(1):54-61. Go to original source... Go to PubMed...
  7. Vlachopoulos CV, Terentes­‑Printzios DG, Ioakeimidis NK, et al. Prediction of cardiovascular events and all­‑cause mortality with erectile dysfunction: a systematic review and meta­‑analysis of cohort studies. Circ Cardiovasc Qual Outcomes. 2013 Jan 1;6(1):99-109. Go to original source... Go to PubMed...
  8. Zhao B, Hong Z, Wei Y, et al. Erectile Dysfunction Predicts Cardiovascular Events as an Independent Risk Factor: A Systematic Review and Meta­‑Analysis. J Sex Med. 2019 Jul;16(7):1005-1017. Go to original source... Go to PubMed...
  9. Seftel AD, de la Rosette J, Birt J, et al. Coexisting lower urinary tract symptoms and erectile dysfunction: a systematic review of epidemiological data. Int J Clin Pract. 2013 Jan;67(1):32-45. Go to original source... Go to PubMed...
  10. Rosen R, Altwein J, Boyle P, et al. Lower urinary tract symptoms and male sexual dysfunction: the multinational survey of the aging male (MSAM-7). Eur Urol. 2003 Dec;44(6):637-49. Go to original source... Go to PubMed...
  11. Salonia A, Minhas S, Betocchi C, et al. Sexual and Reproductive Health. EAU Guidelines. Arnhem: EAU Guidelines Office; 2022. Available from: https://uroweb.org/guidelines/sexual­‑and­‑reproductive­‑health.
  12. Brock G, Ni X, Oelke M, et al. Efficacy of Continuous Dosing of Tadalafil Once Daily vs Tadalafil On Demand in Clinical Subgroups of Men With Erectile Dysfunction: A Descriptive Comparison Using the Integrated Tadalafil Databases. J Sex Med. 2016 May;13(5):860-75. Go to original source... Go to PubMed...
  13. Lee HW, Lee MS, Kim TH, et al. Ginseng for Erectile Dysfunction: A Cochrane Systematic Review. World J Mens Health. 2022 Apr;40(2):264-269. Go to original source... Go to PubMed...
  14. Xu J, Xu Z, Ge N, et al. Association between folic acid, homocysteine, vitamin B12 and erectile dysfunction­‑A cross­‑sectional study. Andrologia. 2021 Dec;53(11):e14234. Go to original source... Go to PubMed...




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