Rok 2011 - klid před bouří?

Mgr. Michal Hojný

Prakt. lékáren. 2011; 7(1): 3  

Current pharmacotherapy for chronic pulmonary hypertension

MUDr.Pavel Jansa, prof.MUDr.Michael Aschermann, DrSc., prof.MUDr.Aleš Linhart, DrSc.

Prakt. lékáren. 2011; 7(1): 13-15  

Pulmonary hypertension is a syndrome characterized by increased pressure in the pulmonary artery. Specific pharmacotherapy is mostly used in pulmonary arterial hypertension (PAH) which is a primary disease of the pulmonary arterioles. In other types of pulmonary hypertension (pulmonary hypertension in left-heart and lung disease and chronic thromboembolic pulmonary hypertension), pharmacotherapy is less often used. Pharmacotherapy for PAH can be arbitrarily divided into conventional (treatment for heart failure, anticoagulation treatment) and specific (calcium channel blockers, prostanoids, endotheline receptor antagonists and phosphodiesterase-5...

Human embryonic development and its affecting by medicaments I.

prof.MUDr.Pavel Trávník, DrSc.

Prakt. lékáren. 2011; 7(1): 17-19  

Characterization of developmental periods and environmental influencing of the embryo This paper reviews human embryonic development in relationship to the medicaments application, their benefits and adverse effects. In the first article individual periods of the development (preconception period, blastogenesis, organogenesis and foetal period) and principles of environmental affecting of the embryo were characterized.

Erectile dysfunction treatment

MUDr.Ondřej Trojan

Prakt. lékáren. 2011; 7(1): 20-23  

The article presents the fundamentals of treatment for erectile dysfunction reviewing the experience from the first decade of existence of PDE-5 inhibitors. Previously published facts are summarized supplemented with new knowledge in order to provide a most accurate outline for everyday use in the present day. injections, prostaglandines, psychotherapy.

Niacin-laropiprant combination: novel approach not only to treatment of dyslipidemia

MUDr.Michal Vrablík, Ph.D., MUDr.Eva Motyková, prof.MUDr.Richard Češka, CSc.

Prakt. lékáren. 2011; 7(1): 7-11  

Complex management of dyslipidemia provides a chance of further reduction of atherosclerotic vascular complications beyond current therapeutic options. A nicotinic acid (niacin) offers a substantial modification of triglyceride and HDL-cholesterol levels together with beneficial impact on LDL-cholesterol and Lp (a) concentrations. Interacting with GPR109A receptors on the surface of hepatocytes, adipocytes and other tissues, niacin induces numerous metabolic changes, thus, explaining its desirable as well as harmful effects. Niacin administration mostly in combination with a statin was associated with a significant slowing of progression or...

Huperzine A and other natural substances in treating Alzheimer's disease

PharmDr.Jan Martin, Ph.D., Mgr.Zuzana Kršková, doc.RNDr.Jaroslav Dušek, CSc.

Prakt. lékáren. 2011; 7(1): 39-41  

Alzheimer's disease is a progressive neurodegenerative process which affects a significant proportion of the population, particularly those over 65 years of age. The disease is associated with deficits and disorders of a number of neurotransmitter systems, in particular the cholinergic one. Currently, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors appear to be the most promising therapeutic agents. Even among naturally occurring compounds, there are inhibitors of these enzymes and many of them are more effective than those used in the medical practice. For instance, huperzine A has more profound effects and exhibits...

New medicinal substances in extemporaneous prescription, part 6 - triamcinolone acetonide

PharmDr.Zbyněk Sklenář, Ph.D., PharmDr.Jan Hašek

Prakt. lékáren. 2011; 7(1): 25-29  

Triamcinolone acetonide is a synthetic fluorinated corticosteroid, a well-known drug in clinical practice. It has been available since November 2010 as a pharmaceutical substance, so the number of corticosteroids used for extemporaneous preparation in pharmacies has increased. This article provides information on the properties and use of this substance applied mainly in dermatology, shows the options of incorporating and presents examples of formulas suitable for magistral preparation. There is a possibility of extemporaneous preparation in the case of outage of production of proprietary medicinal products contaning triamcinolone acetonide.

New medicinal substances in extemporaneous prescription, part 7 - alpha-tocopherol acetate

PharmDr.Zbyněk Sklenář, Ph.D., Mgr.Kateřina Horáčková

Prakt. lékáren. 2011; 7(1): 30-33  

Alpha-tocopherol acetate has been used as medicinal substance (vitamin E) for peroral, parenteral and topical preparationes. The aim of the article is not to present the sometimes questionable therapeutic use of tocopherols but to provide basic information on the properties and use of this substance and to present suitable examples of formulas because tocopherol is still used in some prescriptions of extemporaneous preparations. The formulation can be easier now because alpha-tocopherol acetate has been available as a substance for extemporaneous preparation in pharmacies since October 2010.

Means of skin protection against harmful effects of UV radiation

PharmDr.Miroslav Miletín, Ph.D.

Prakt. lékáren. 2011; 7(1): 34-38  

Harmful effects of UV radiation on skin, especially for the fair one, are generally recognized fact, even if a small dose of the UV radiation is necessary to run some important physiological processes. The main risk factor is an undisputable cancerogenic effect, however, there are also unfavourable cosmetic impacts. In the case it is not possible to avoid the UV radiation exposition, or someone even wants to sunbath, effective protection against the harmful of the UV radiation consequences employing UV filters (sunscreens) is highly desirable. The scale of these means is quite wide, including several structural types of chemical organic filters...

zvoleno 11 členů výboru a 3 členové revizní komise. Výbor si ze svých řad zvolil tyto funkcionáře.

PharmDr.Pavel Grodza

Prakt. lékáren. 2011; 7(1): 44  

Historický kalendář na rok 2011

RNDr.Pavel Drábek

Prakt. lékáren. 2011; 7(1): 42-43  

Kombinace niacinu s laropiprantem: další možnost ovlivnění nejen dyslipidemie. Komentář ke článku (Prakt. lékáren. 2011; 7(1): 7-11)

doc.PharmDr.Martin Doležal, Ph.D.

Prakt. lékáren. 2011; 7(1): 12  

Autodidaktický test 1/2011

Prakt. lékáren. 2011; 7(1): 45-46