Some issues of antidepressant efficacy and tolerability relevant for routine clinical practice

prof. MUDr. Eva Češková, CSc.

Prakt. Lékáren. 2016; 12(5e)  

Current possibilities of available antidepressants (AD) are limited. In spite of great heterogeneity of depressive disorders, monoaminesremain the main target of psychopharmacotherapy. The differences in treatment response are associated with genetic variability. The developing field of pharmacogenetics strives for individualized treatment; however, in routine clinical practice the choice of antidepressantis based on individual efficacy, tolerability and alignment of symptoms to a biochemical alteration. The presence of an adequate quantityof the active substance in CNS targets is undoubtedly a precondition for efficacy. This raises the issue of adherence....

Constipation in children, diagnosis and treatment

MUDr. Eliška Hloušková

Prakt. Lékáren. 2016; 12(5e): e3-e9 | DOI: 10.36290/lek.2016.094  

Constipation is a common issue addressed in the general paediatrician’s surgery. It is manifested by infrequent, difficult passage of stools. Fromthe clinical perspective, it is important to distinguish organic and functional constipation. Organic constipation is evidenced by numerous warningsigns and any suspicion should result in early referral of the child to a specialist. Functional constipation is much more frequent. It occurs asa result of experience with painful defecation and the fear of it being repeated, with the child resisting defecation actively. The treatment is basedon several simultaneously occurring steps: education, clearing...

Drug poisoning is the most common reason for consultation Poison Information Centre (TIC) in children and adults

Hana Rakovcová

Prakt. Lékáren. 2016; 12(5e): e10-e17 | DOI: 10.36290/lek.2016.085  

The usual cause of drug poisoning of children are accidents and medical errors. In adolescents and adults, it is mainly about the suicide attempts.After exposure to toxic doses of drugs are applied methods of primary decontamination (before absorption of the drug), symptomatic therapy,rarely antidotes and exceptionally secondary elimination methods (after the absorption of drugs into circulation and tissues).

Treatment of multiple myeloma yesterday, today and tomorrow – repetition for pharmacists

Martina Novosadová

Prakt. Lékáren. 2016; 12(5e): e25-e37 | DOI: 10.36290/lek.2016.095  

Multiple myeloma (MM) is a cancer resulting from a malignant transformation of plasma cells. Early diagnosis and causal therapy improvesquality of life and increases a chance to multi-year survival. The basis of treatment is always causal combination chemotherapy, in patientsunder 65 years of age combined with autologous bone marrow transplantation. This article summarizes the most common symptoms,diagnosis, treatment and supportive modality in patients with multiple myeloma. Furthermore, an overview of treatment options, includingthe latest innovations in the treatment of MM.

E-verze 5/16

Prakt. Lékáren. 2016; 12(5e)