Pharmacy for Practice, 2018, issue 3

Editorial

Má ještě profese lékárníka svobodný charakter?

PharmDr. Antonín Svoboda

Prakt. lékáren. 2018; 14(3)

Current pharmacotherapy

Pharmacotherapy of Alzheimer disease and neuropsychiatric symptoms of dementia

Iva Prokopová

Prakt. lékáren. 2018; 14(3): 109-112

Alzheimer disease is the most prevalent cause of dementia. A precise diagnosis is required for effective management. Cholinesteraseinhibitors are used as first line therapy to provide modest symptomatic benefit in some patients, memantine appears tohave modest benefits in patients with moderate to severe disease. Neuropsychiatric symptoms are common in dementia andcontribute to nursing home admission and caregiver stress. Identifying the genesis of the abnormal behavior is critical, in orderthat nonpharmacologic therapies are preferred over medication. Symptomatic pharmacologic treatment includes antidepressants,antipsychotics, anxiolytics and other...

Therapy of acute upper respiratory tract infections

Petr Schalek

Prakt. lékáren. 2018; 14(3): 115-118 | DOI: 10.36290/lek.2018.022

Acute upper respiratory tract infections affect both children and adults and for their frequency represent a serious health andsocio-economic problem. The main goal of treatment for these infections is to alleviate symptoms, shorten the duration of illness,avoid complications, and reduce school or work absenteeism. The following brief overview lists the groups of drugs that are oftenrecommended or prescribed for patients with acute upper respiratory infections, with an emphasis on evidence-based medicine.

NSAIDs in the acute pain treatment from the viewpoint of a neurologist

Tomáš Nežádal

Prakt. lékáren. 2018; 14(3): 120-126

Nonsteroidal anti-inflammatory drugs (NSAIDs) have a common analgesic, antipyretic and at higher doses in particular antiphlogisticeffect that differs this pharmacological group from other non-opioid analgesics. The term non-steroidal define these substancesin 1960 against the steroids administred in rheumatology. These are some of the most commonly used drugs. Neurologist's viewon the NSAIDs is not too revealing, but spectrum of NSAIDs in neurology is wide, with acute and chronic pain conditions, fromvertebral and radicular syndromes to migraines and a large group of other headaches. This insight tries to chart the position ofNSAIDs among other analgesics,...

The most common mistakes in the treatment of depression in primary care

Sylva Racková

Prakt. lékáren. 2018; 14(3): 127-131

Depression belongs among very frequent and well treated disorders. It is important to follow the guidelines in the treatmentdepression. We are concerned with farmacotheraphy of depression, what is important and witch mistakes are more frequent inthe pharmacotheraphy.

Medicamenta nova

Apremilast in dermatology

MUDr. Dana Prusíková

Prakt. lékáren. 2018; 14(3): 104-108

Current system therapy represents in some cases a compromise between the safety and efficacy of treatment, the route of administration(injection x oral form) and the need for laboratory monitoring during treatment. In particular, the safety of treatmentis an important factor in patients with psoriasis in selecting a particular treatment due to the presence of frequent comorbiditiessuch as diabetes mellitus or cardiovascular disease. Apremilast as a selective PDE4 inhibitor increases cAMP levels and acts specificallyon intracellular signaling, gene and protein expression. It reduces the inflammatory response by reducing the expressionof proinflammatory...

Phytotherapy

Gymnena sylvestre in a therapy of diabetes mellitus

Zdeňka Navrátilová

Prakt. lékáren. 2018; 14(3): 132-134 | DOI: 10.36290/lek.2018.026

Gymnema sylvestre, also known as gurmar, is an evergreen climber originated in tropical Asia, Africa and Australia. It has been usedfor centuries in traditional ayurvedic medicine for treatment of many illnesses, such as diabetes, obesity, malaria, skin diseases,asthma, cough, inflammations, infections, and snakebite. The research has identified the main active components as oleanan- anddammarane‑typetriterpenic saponins (gymnemic acids, gymnemasaponins, and gymnemosides). Antidiabetic and hypolipidemiceffects were confirmed in animal studies and clinical trials, further research continues.

Comment

Stručný přehled farmakologických možností léčby bolesti u dětí - komentář

MUDr. Petra Matalová, Ph.D.

Prakt. lékáren. 2018; 14(3): 126

Self-treatment

Options of self-treatment in increased fatigue: What a pharmacist can advise

Vilma Vranová

Prakt. lékáren. 2018; 14(3): 135-139 | DOI: 10.36290/lek.2018.027

Fatigue is usually defined as a subjective feeling of weariness, lack of energy, and exhaustion. An inability to find the right amountand type of rest is the cause of many illnesses leading, for instance, to impaired defence against infections; dysfunction and diseaseof the cardiovascular system; gastrointestinal, urogenital, and autoimmune diseases; backache; as well as oncological diseases.The treatment for chronic fatigue is based on determination of objective causes of its development and their elimination. Thepresent article mainly deals with the issue of supportive treatment with registered phytopharmaceuticals.

Cleaning systems in care of contact lenses – how to recommend a suitable cleaning solution in the pharmacy and how to educate the customer about it’s proper use

Veronika Bucharová

Prakt. lékáren. 2018; 14(3): 140-142 | DOI: 10.36290/lek.2018.028

Contact lenses are very common corrective aid that is nowadays frequently used. It is important to take care of the contact lensesproperly for their comfortable and safe wearing as to follow certain principles that help to prevent infectious and non‑infectiouscomplications. For care of the contact lenses we use different solutions and it is necessary to adapt their choice to the individualuser’s needs.