Praktické lékárenství, 2019, issue 2

Editorial

Spolek farmaceutů v Brně

PharmDr. Martin Šimíček

Prakt. lékáren. 2019; 15(2): 59

Current pharmacotherapy

Osteoporosis – 2nd part, pharmacotherapy

Petra Matalová

Prakt. lékáren. 2019; 15(2): 64-69

Therapies of osteoporosis can be varied. Delivery of sufficient levels of calcium, synthesis of vitamin D in the skin and physicalactivity are the most successful. When these nutrients are lacking, they need to be artificially added via use of medicaments.The second most common method of therapy incorporates mainly bisphosphonates. Osteoanabolic therapy is also used. Thereis a possibility of targetted therapy as well. The use of therapy has to be long. In these cases of prolonged therapies and oftenasymptomatic diseases, the most important factor is the patient´s compliance and adherence.

New treatment options for relapsing-remitting multiple sclerosis

Radek Ampapa

Prakt. lékáren. 2019; 15(2): 70-73 | DOI: 10.36290/lek.2019.013

In recent years, the treatment options for relapsing-remitting multiple sclerosis have expanded considerably. Cladribine and ocrelizumab are novel drugs intended for the treatment of patients with the active form of this chronic disease. Both drugs have been shown to have a high efficacy in large clinical trials in which there was a reduction in the clinical and radiological activity of multiple sclerosis compared with placebo or active comparator. In comparison with the commonly used current treatment, both drugs have an attractive administration pattern that increases patient adherence to treatment. The safety profile is favourable, with no case...

Specifics of neonatal pharmacotherapy

Andrea Staníková

Prakt. lékáren. 2019; 15(2): 74-76 | DOI: 10.36290/lek.2019.038

Pharmacologic therapies have made a significant contribution to reducing both mortality and morbidity in neonates. A particularproblem in neonates is the off-label use of medicines. This reflects the lack of scientific evidence and availability of appropriatelicensed formulations in neonatology. Unfortunately, for most drugs there is a lack of oral formulations for neonates. Use ofmagistral formulations is therefore part of daily neonatal practice. This article discusses the developmental changes in neonatalperiod and the most frequent problems in neonatal clinical pharmacology.

Cardiovascular pharmacotherapy in childhood

Karel Koubský, Jan Janoušek, Václav Chaloupecký

Prakt. lékáren. 2019; 15(2): 77-81 | DOI: 10.36290/lek.2019.039

The article summarises current medical treatment of heart failure, pulmonary hypertension and heart rhythm disorders in children.Pharmacologic manipulation of the arterial duct in newborns with critical congenital heart defects is also addressed.

Current trends in the hormone replacement therapy

Pavel Trávník

Prakt. lékáren. 2019; 15(2): 82-84 | DOI: 10.36290/lek.2019.014

In past decades the hormonal replacement therapy was often the subject of discussion. In the last several years the opinionconcerning the suitability, indications, and contraindications of this therapy stabilizes. In the paper the conclusions of recentpublications and statements of professional societies are given.

Phytotherapy

Propolis as an anti-inflammatory and antibacterial agent

Karel Šmejkal

Prakt. lékáren. 2019; 15(2): 85-89 | DOI: 10.36290/lek.2019.015

Propolis is a multicomponent product of bees containing a number of biologically active substances. The composition of propolis varies a lot, depending on seasonal conditions, time of collection, and plant resources available to collecting bees. It contains a variety of phenolic substances, such as phenolic acids and flavonoids. Propolis has traditionally been used to treat a wide range of diseases; however, major interest is focused on its antibacterial, anti-inflammatory, and immunomodulatory effects. For practical use, the most common technique of processing propolis is washing with water and ethanol extraction in order to produce a propolis balm...

Pharmaceutical technology

Topical corticosteroids in extemporaneous prescription, part 1

Jan Hašek

Prakt. lékáren. 2019; 15(2): 111-116 | DOI: 10.36290/lek.2019.021

Glucocorticoids are the strongest known anti-inflammatory agents. They are used broadly in various medical disciplines. The present article is aimed at the dermatological formulation. It deals with the aspects affecting absorption of topical corticosteroids from the vehicles as well as with the classification of individual agents based on effect strength, and provides notes on the therapeutic index of selected compounds. In terms of magistral preparation, galenic properties of topical corticosteroids are presented, as are the possibilities of formulating substances into a compounded drug in general terms. Also presented are the factors affecting stability....

Information

Terapie rhinitidy

Vilma Vranová, Karel Vašut

Prakt. lékáren. 2019; 15(2): 106-110

Self-treatment

How can we help a patient in a pharmacy with a choice of probiotics?

Karel Hrnčiarik, Sylva Píšová

Prakt. lékáren. 2019; 15(2): 96-100 | DOI: 10.36290/lek.2019.017

Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host.They are mainly bifidobacteria, lactobacilli, streptococci, enterobacteria, Bacillus coagulans and Saccharomyces boulardii.There are hundreds of probiotic diet supplements on the Czech market, in which the experienced pharmacist is also difficultto orientate. The article summarizes interesting information for practice including examples of interesting probiotics.Furthermore, the issue of travel diarrhea is mentioned.

Over the counter medications in the treatment of feet’s dermatophytosis

Markéta Obrovská

Prakt. lékáren. 2019; 15(2): 101-102 | DOI: 10.36290/lek.2019.018

Athlete’s foot – Tinea pedis is common fungal disease which could be seen not only in adults. The article sums up over the countertreatment options. There is also description of preventive procedures which increase efficiency of treatment and which protectpatient against the recurrence.

Photoprotection

Olga Nedopílková

Prakt. lékáren. 2019; 15(2): 103-105 | DOI: 10.36290/lek.2019.019

Sunbathing is a very popular aktivity in the summer months, usually during the holliday. However, in addition to positive effectson human health, sunlight has negative effects that we should protect against. A large number of sunscreens with a wide rangeof sun protection factor (SPF) are available on the market. However, sunscreens are not the only suitable photoprotection againstthe negative effects of solar radiation.