Praktické lékárenství, 2019, E-verze 4/19
Current pharmacotherapy
Overview of ophthalmic dosage forms
Lukáš Láznička, Zdeňka Šklubalová
Prakt. Lékáren. 2019; 15(4e): 3-8 
For the treatment and prevention of ocular diseases, most patients are treated with conventional drug delivery formulations such as eye drops orointments. Their disadvantage is the low bioavailability of the drug and frequent application. The new trends in the development of ophthalmicpreparations include the use of modern excipients and dosage forms to achieve higher bioavailability of the drug. However, only a few modern deviceshave come into common clinical practice while others are being investigated in clinical trials.
Drug-induced lung injury
Vladimíra Lošťáková, Milan Kuna, Vítězslav Kolek, Filip Čtvrtlík, Gabriela Vaculová
Prakt. Lékáren. 2019; 15(4e): 9-30
The treatment of various types of diseases can be associated with a number of adverse side effects of drugs. Drugs that can cause lung disease are constantly on the increase. This is due to not only the development of new drugs, but also the use of modern diagnostic means allowing more accurate investigation. The mainstay of diagnosing drug-induced injury is the identification of a drug that, with certain probability, could have induced lung injury. To identify it among other drugs that a patient is taking as well as to distinguish drug-induced injury from a possible exacerbation of an existing lung disease is difficult. The most common drugs that...
Corticosteroids – therapy of the first choice?
doc. MUDr. Edvard Ehler, CSc.
Prakt. Lékáren. 2019; 15(4e): 31-37
in pathogenesis of CIDP are primarily of humoral and also cellular immunity. In CIDP, the most frequent is classical form, which is characterized by clinically nearly symmetric and electrophysiologically multifocal impairment of motor and sensory fibers. Therapy of CIDP is initiated by „induction therapy“, consisting of corticosteroids, intravenous administration of high doses of immunoglobulins (IVIG) or therapeutic plasma exchange (TPE). In view of the high demands on the equipment and of more frequent adverse reactions in TPE, the use of corticosteroids or IVIG is the therapy of the first choice. In comparison with steroids the administration...
Neuropathic pain treatment
Marek Hakl
Prakt. Lékáren. 2019; 15(4e): 38-44
Neuropathic pain is one of the most difficult pain condition to treat. Many common analgesics are ineffective in treating it. In therapy to theforefront are coming above all mainly a group of drugs from anticonvulsants, anti depressives, opioids with increased affinity to neuropathicpain and lately new topical form of medicaments. Occurrence of the neuropathic pain is increasing exponentially with the age of the patients,and at the same time the tolerance of the patients to anti neuropathic treatment is decreasing. Major benefit to treatment of the neuropathic pain was formation of unified EFNS guidelines on which the national guidelines...
Clinical pharmacy
Is the calcium supplementation in palliative care always unnecessary?
Judita Kudělová, Michaela Šlesingerová, Jana Gregorová
Prakt. Lékáren. 2019; 15(4e): 45-51
Disruption of calcium homeostasis is a common complication in oncological patients, particularly in patients with metastatic bone disorder. Imbalance of bone metabolism may lead to hypercalcaemia or to less common hypocalcaemia. The following article presents a case report of a patient with diagnosis of a lung cancer. Significant hypocalcaemia was detected at the time of hospital admission. After initial intravenous mineral supplementation therapy, the deficiency of vitamin D was considered within the differential diagnosis of hypocalcaemia. Subsequent vitamin D metabolite blood test confirmed serious hypovitaminosis. Based on the laboratory findings,...