Prakt. lékáren. 2017; 13(3): 103-105 | DOI: 10.36290/lek.2017.061

Antidepressant therapy during pregnancy

Lenka Sušilová
Ústav ochrany a podpory zdraví, LF MU Brno

Antidepressant therapy during pregnancy which is sometimes necessary in clinical practice poses certain risks. Although theserisks are relatively small, according to results of studies so far, it is still necessary to consider them in the treatment. The choice ofantidepressant should be individually considered for each patient.

Keywords: pregnancy, treatment, pharmacotherapy, antidepressant agents, dual-action antidepressant

Received: April 17, 2018; Accepted: April 22, 2018; Published: October 1, 2017  Show citation

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Sušilová L. Antidepressant therapy during pregnancy. Praktické lékárenství. 2017;13(3):103-105. doi: 10.36290/lek.2017.061.
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References

  1. Bonari L, Pinto N, Ahn E, et al. Perinatal risks of untreated depression during pregnancy. Can J Psychiatr 2004; 49: 726-735. Go to original source... Go to PubMed...
  2. Wiesner K, Sit D, Hanusa B, et al. Major depression and antidepressant treatment: impact on pregnancy and neonatal outcomes. Am J Psychiatry 2009; 166: 557-566. Go to original source... Go to PubMed...
  3. Mohr P, Praško J, Bareš M, et al. Psychické poruchy v graviditě a laktaci. In: Seifertová D, et al. Postupy v léčbě psychických poruch. Praha: Academia Medica Pragensis 2008: 484-497.
  4. Becker M, Weinberger T, Chandy A, Schmukler S. Depression During Pregnancy and Postpartum. Curr Psychiatry Rep. 2016; 18(3): 32. Go to original source... Go to PubMed...
  5. Pariante C, Seneviratne G, Howard L. Should we stop using tricyclic antidepressants in pregnancy? Psychol Med 2011; 41: 15-17. Go to original source... Go to PubMed...
  6. Gentile S. Tricyclic antidepressants in pregnancy and puerperium. Expert Opin Drug Saf 2014; 13(2): 207-225. Go to original source... Go to PubMed...
  7. Gentile S. On categorizing gestational, birth, and neonatal complications following late pregnancy exposure to antidepressants: the prenatal antidepressant exposure syndrome. CNS Spectr 2010; 15: 167-185. Go to original source... Go to PubMed...
  8. Hale T, Kendall-Tackett K, Cong Z, et al. Discontinuation syndrome in newborns whose mothers took antidepressants while pregnant or breastfeeding. Breastfeed Med 2010; 5: 283-288. Go to original source... Go to PubMed...
  9. Bérard A, Zhao JP, Sheehy O. Antidepressant use during pregnancy and the risk of major congenital malformations in a cohort of depressed pregnant women: an updated analysis of the Quebec Pregnancy Cohort. BMJ Open 2017; 7(1): e013372. Go to original source... Go to PubMed...
  10. Bérard A, Iessa N, Chaabane S, Muanda FT, Boukhris T, Zhao JP. The risk of major cardiac malformations associated with paroxetine use during the first trimester of pregnancy: a systematic review and meta-analysis. Br J Clin Pharmacol 2016; 81(4): 589-604. Go to original source...
  11. Bar-Oz B, Einarson T, Einarson A, Boskovic R, O'Brien L, Malm H, Bérard A, Koren G. Paroxetine and congenital malformations: meta-analysis and consideration of potential confounding factors. Clin Ther 2007; 29: 918-926. Go to original source...
  12. El Marroun H, Jaddoe V, Hudziak J, et al. Maternal use of selective serotonin reuptake inhibitors, fetal growth, and risk of adverse birth outcomes. Arch Gen Psychiatry 2012; 69: 706-714. Go to original source...
  13. Broy P, Bérard A. Gestational exposure to antidepressants and the risk of spontaneous abortion: a review. Curr Drug Deliv 2010; 7: 76-92. Go to original source...
  14. Bérard A, Sheehy O, Zhao JP, Vinet É, Bernatsky S, Abrahamowicz M. SSRI and SNRI use during pregnancy and the risk of persistent pulmonary hypertension of the newborn. Br J Clin Pharmacol 2017; 83(5): 1126-1133. Go to original source...
  15. Sie SD, Wennink JM, van Driel JJ, et al. Maternal use of SSRIs, SNRIs and NaSSAs: practical recommendations during pregnancy and lactation. Arch Dis Child Fetal Neonatal Ed 2012; 97(6): F472-476. Go to original source... Go to PubMed...
  16. Louik C, Kerr S, Mitchell AA. First-trimester exposure to bupropion and risk of cardiac malformations. Pharmacoepidemiol Drug Saf 2014; 23(10): 1066-1075. Go to original source...
  17. Djulus J, Koren G, Einarson TR, et al. Exposure to mirtazapine during pregnancy: a prospective, comparative study of birth outcomes. J Clin Psychiatry 2006; 67(8): 1280-1284. Go to original source... Go to PubMed...
  18. Nakhai-Pour Hr, Broy P, Bérard A. Use of antidepressants during pregnancy and the risk of spontaneous abortion. CMAJ 2010; 182: 1031-1037. Go to original source... Go to PubMed...
  19. Chun-Fai-Chan B, Koren G, Fayez I, et al. Pregnancy outcome of women exposed to bupropion during pregnancy: a prospective comparative study. Am J Obstet Gynecol 2005; 192(3): 932-936. Go to original source... Go to PubMed...
  20. Byatt N, Deligiannidis KM, Freeman MP. Antidepressant use in pregnancy: a criticaleview focused on risks and controversies. Acta Psychiatr Scand 2013; 127(2): 94-114. Go to original source... Go to PubMed...
  21. Boukhris T, Sheehy O, Mottron L, Bérard A. Antidepressant Use During Pregnancy and the Risk of Autism Spectrum Disorder in Children. JAMA Pediatr 2016; 170(2): 117-124. Go to original source... Go to PubMed...
  22. Švestka J, Mohr P. Agomelatin, melatoninové a noradrenalinové/dopaminové antidepresivum mechanismus účinku a klinické důsledky. Farmakoterapie 2012; 8(3): 256-263.
  23. Valdoxan. Souhrn ůdajů o přípravku 03/2012; dostupné na http://www.ema.europa.eu.
  24. Carvalho AF, Sharma MS, Brunoni AR, Vieta E, Fava GA. The Safety, Tolerability and Risks Associated with the Use of Newer Generation Antidepressant Drugs: A Critical Review of the Literature. Psychother Psychosom 2016; 85(5): 270-288. Go to original source... Go to PubMed...
  25. Citrome L. Vortioxetine for major depressive disorder: a sys-tematic review of the efficacy and safety profile for this newly approved antidepressant - What is the number needed to treat, number needed to harm and likelihood to be helped or harmed? Int J Clin Pract 2014; 68(1): 60-82. Go to original source... Go to PubMed...




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