Prakt. lékáren. 2017; 13(3): 116-118 | DOI: 10.36290/lek.2017.015

Gynostemma pentaphyllum – active compounds and therapeutic effects

Zdeňka Navrátilová
Katedra botaniky, Přírodovědecká fakulta, Univerzita Karlova, Praha

Gynostemma pentaphyllum is a perennial herb originating from Southeast Asia where it is known as jiaogulan. Many bioactivecompounds were isolated from aerial parts of this plant; the main pharmacologically active components of jiaogulan are thegypenosides, which are dammarane-type triterpene saponins. Recent studies confirm numerous pharmacological effects ofjiaogulan, the most promising is its antidiabetic, anti-cancer and neuroprotective activity.

Keywords: Gynostemma pentaphyllum, jiaogulan, gypenosides, antidiabetic, anti-cancer and neuroprotective effects

Published: October 1, 2017  Show citation

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Navrátilová Z. Gynostemma pentaphyllum – active compounds and therapeutic effects. Praktické lékárenství. 2017;13(3):116-118. doi: 10.36290/lek.2017.015.
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References

  1. Liu Y, Wang Z, Zhang J (eds.). Dietary Chinese Herbs: Chemistry, Pharmacology and Clinical Evidence. Springer 2015; 802 p. Go to original source...
  2. Zhang XS, Cao JQ, Zhao C, Wang XD, Wu XJ, Zhao YQ. Novel dammarane-type triterpenes isolated from hydrolyzate of total Gynostemma pentaphyllum saponins. Bioorg Med Chem Lett. 2015; 25(16): 3095-3099. Go to original source... Go to PubMed...
  3. Cui J, Eneroth P, Bruhn JG. Gynostemma pentaphyllum: identification of major sapogenins and differentiation from Panax species. Eur J Pharm Sci. 1999; 8(3): 187-191. Go to original source... Go to PubMed...
  4. Razmovski-Naumovski V, Huang THW, Tran VH, Li GQ, Duke CC, Roufogali BD. Chemistry and Pharmacology of Gynostemma pentaphyllum. Phytochem Rev. 2005; 4: 197-219. Go to original source...
  5. Li Y, Lin W, Huang J, Xie Y, Ma W. Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan). Chin Med. 2016; 11: 43. Go to original source... Go to PubMed...
  6. Wagner H, Ulrich-Merzenich G (eds.). Evidence and Rational Based Research on Chinese Drugs. Springer-Verlag Wien 2013; 525 p. Go to original source...
  7. Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Antidiabetic effect of Gynostemma pentaphyllum tea in randomly assigned type 2 diabetic patients. Horm Metab Res. 2010; 42(5): 353-357. Go to original source... Go to PubMed...
  8. Huyen VT, Phan DV, Thang P, Ky PT, Hoa NK, Ostenson CG. Antidiabetic effects of add-on Gynostemma pentaphyllum extract therapy with sulfonylureas in type 2 diabetic patients. Evid Based Complement Alternat Med. 2012; 2012: 452313. Go to original source... Go to PubMed...
  9. Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Gynostemma pentaphyllum tea improves insulin sensitivity in type 2 diabetic patients. J Nutr Metab. 2013; 2013: 765383. Go to original source... Go to PubMed...
  10. Qin R, Zhang J, Li C, Zhang X, Xiong A, Huang F, Yin Z, Li K, Qin W, Chen M, Zhang S, Liang L, Zhang H, Nie H, Ye W. Protective effects of gypenosides against fatty liver disease induced by high fat and cholesterol diet and alcohol in rats. Arch Pharm Res. 2012; 35(7): 1241-1250. Go to original source... Go to PubMed...
  11. Yang YH, Yang J, Jiang QH. Hypolipidemic effect of gypenosides in experimentally induced hypercholesterolemic rats. Lipids Health Dis. 2013; 12: 154. Go to original source... Go to PubMed...
  12. Park SH, Huh TL, Kim SY, Oh MR, Tirupathi Pichiah PB, Chae SW, Cha YS. Antiobesity effect of Gynostemma pentaphyllum extract (actiponin): a randomized, double-blind, placebo-controlled trial. Obesity (Silver Spring). 2014; 22(1): 63-71. Go to original source... Go to PubMed...
  13. Chou SC, Chen KW, Hwang JS, Lu WT, Chu YY, Lin JD, Chang HJ, See LC. The add-on effects of Gynostemma pentaphyllum on nonalcoholic fatty liver disease. Altern Ther Health Med. 2006; 12(3): 34-39.
  14. Meng X, Wang M, Sun G, Ye J, Zhou Y, Dong X, Wang T, Lu S, Sun X. Attenuation of A?25-35-induced parallel autophagic and apoptotic cell death by gypenoside XVII through the estrogen receptor-dependent activation of Nrf2/ARE pathways. Toxicol Appl Pharmacol. 2014; 279(1): 63-75. Go to original source... Go to PubMed...
  15. Shin KS, Zhao TT, Park KH, Park HJ, Hwang BY, Lee CK, Lee MK. Gypenosides attenuate the development of L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned rat model of Parkinson's disease. BMC Neurosci. 2015; 16: 23. Go to original source... Go to PubMed...
  16. Hong SW, Yang JH, Joh EH, Kim HJ, Kim DH. Gypenoside TN-2 ameliorates scopolamine-induced learning deficit in mice. J Ethnopharmacol. 2011; 134(3): 1010-1013. Go to original source... Go to PubMed...
  17. Kim KS, Zhao TT, Shin KS, Park HJ, Cho YJ, Lee KE, Kim SH, Lee MK. Gynostemma pentaphyllum ethanolic extract protects against memory deficits in an MPTP-lesioned mouse model of Parkinson's disease treated with L-DOPA. J Med Food. 2017; 20(1): 11-18. Go to original source... Go to PubMed...
  18. Choi HS, Zhao TT, Shin KS, Hwang BY, Lee CK, Lee MK. Anxiolytic effects of herbal ethanol extract from Gynostemma pentaphyllum in mice after exposure to chronic stress. Molecules. 2013; 18(4): 4342-4356. Go to original source... Go to PubMed...
  19. Zhao TT, Shin KS, Choi HS, Lee MK. Ameliorating effects of gypenosides on chronic stress-induced anxiety disorders in mice. BMC Complement Altern Med. 2015; 15: 323. Go to original source... Go to PubMed...
  20. Chiranthanut N, Teekachunhatean S, Panthong A, Khonsung P, Kanjanapothi D, Lertprasertsuk N. Toxicity evaluation of standardized extract of Gynostemma pentaphyllum Makino. J Ethnopharmacol. 2013; 149(1): 228-234. Go to original source... Go to PubMed...
  21. Attawish A, Chivapat S, Phadungpat S, Bansiddhi J, Techadamrongsin Y, Mitrijit O, Chaorai B, Chavalittumrong P. Chronic toxicity of Gynostemma pentaphyllum. Fitoterapia. 2004; 75(6): 539-551. Go to original source... Go to PubMed...
  22. Chavalittumrong P, Sriwanthana B, Kijphati R, Jitjuk B, Treesangsri W, Phadungpat S, Boonruad T, Bandsiddhi J, Banjob M. A phase I trial of Gynostemma pentaphyllum in healthy volunteers. Songklanakarin J Sci Technol. 2007; 29(1): 83-93.
  23. He M, Jiang J, Qiu F, Liu S, Peng P, Gao C, Miao P. Inhibitory effects of gypenosides on seven human cytochrome P450 enzymes in vitro. Food Chem Toxicol. 2013; 57: 262-265. Go to original source... Go to PubMed...
  24. Jiaogulan Drug Digest. Dostupné z: http://aumtea.com/reseller/Article%20Jiaogulan%20Drug%20Digest.pdf(16.5.2017).




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