Prakt. lékáren. 2020; 16(2): 97-99 | DOI: 10.36290/lek.2020.016

Transdermal medical preparations available in Czech Republic and basic principles of their application

Andrej Kováčik, Barbora Vraníková
Katedra farmaceutické technologie, Farmaceutická fakulta UK v Hradci Králové

Transdermal application allows to administer the drug through the skin with the systemic effect, without the need for the preparation to be swallowed (oral administration) or for the patient to undergo the invasive application of injection (e.g., intravenous administration). Transdermal delivery offers a wide range of benefits; however, their effect may be significantly affected by the improper technique of the application that differs for each preparation. This paper introduces the basic overview of liquid, semi-solid and solid transdermal delivery systems available in Czech Republic with the specific focus on their correct application.

Keywords: transdermal application, semi‑solid preparations, magistral preparation, transdermal patches.

Published: June 22, 2020  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Kováčik A, Vraníková B. Transdermal medical preparations available in Czech Republic and basic principles of their application. Pharmacy for Practice. 2020;16(2):97-99. doi: 10.36290/lek.2020.016.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Hrabálek A, Vávrová K. Lze překonat kožní bariéru? Prakt. Lék. 2005; 1: 8-11.
    2. Kováčik A, Kopečná M, Vávrová K. Permeation enhancers in transdermal drug delivery: benefits and limitations. Expert Opin. Drug Deliv. 2020; 17(2): 145-155. Go to original source... Go to PubMed...
    3. Wiedersberg S, Guy RH. Transdermal drug delivery: 30+ years of war and still fighting. J. Control. Release. 2014; 190: 150-156. Go to original source... Go to PubMed...
    4. SPC Lenzetto dostupné z: www.sukl.cz/modules/medication/download.php?file=SPC128326.pdf & type=spc & as=lenzetto‑spc (11. 05. 2020).
    5. Rowe RC, Sheskey PJ, Owen SC. Handbook of pharmaceutical excipients. 5th ed. Washington, DC: American Pharmacists Association. 2006; 918 p.
    6. SPC Oestrogel dostupné z: www.sukl.cz/modules/medication/download.php?file=SPC101199.pdf & type=spc & as=oestrogel‑spc (11. 05. 2020).
    7. SPC Testavan dostupné z: www.sukl.cz/modules/medication/download.php?file=SPC155721.pdf & type=spc & as=testavan‑spc (11. 05. 2020).
    8. SPC Androgel dostupné z: www.sukl.cz/modules/medication/download.php?file=SPC126853.pdf & type=spc & as=androgel‑spc (11. 05. 2020).
    9. Klovrzová S, Láznička L. Nové možnosti magistraliter přípravy v dermatologii. Remedia 2015; 25(3): 221-224.
    10. Pastore MN, Kalia YN, Horstmann M, Roberts MS. Transdermal patches: history, development and pharmacology. Brit. J. Pharmacol. 2015; 172: 2179-2209. Go to original source...
    11. Ševčík P, Adam Z. Transdermální buprenorfin. Remedia. 2006; 16(5): 514521.
    12. Vondráčková D. Léčení chronické bolesti pomocí opioidních náplasťových forem. Ambul. Terapia 2007; 5(3-4): 181-187.
    13. Koliba P. Výhody transdermálních forem HRT z pohledu gynekologa. Klin. Farmakol. Farmacie 2015; 29(2): 80-83.
    14. Státní ústav pro kontrolu léčiv dostupné z: www.sukl.cz (11. 05. 2020).

    Return to the content


    Pharmacy for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.