Malé ohlédnutí za dvaceti lety České lékárnické komory

Mgr. Jiří Kotlář

Prakt. lékáren. 2011; 7(4): 155  

Chronic venous disease and its treatment

Lukáš Lacina, Ondřej Kodet, Petr Mitáš, Jiří Štork

Prakt. lékáren. 2011; 7(4): 160-165  

The aim of this article is to review briefly the chronic venous disease (CVD) – one of the most common diseases affecting population of Western countries. The anatomy and physiology of lower extremities venous system are discussed as well as important disturbing factors leading to loss of their function. The article furter dwells on conservative therapy of venous insificiency concerning mainly compressive therapy and pharmacotherapy.

Pathology of folic acid nad pregnancy

Michal Koucký

Prakt. lékáren. 2011; 7(4): 166-170  

Folic acid is a water-soluble vitamin and a member of the vitamin B group. The biological effects are associated with its metabolites, particularly 5-methyl-THF (metafolin). The demand for folic acid increases two- to three-fold during pregnancy. An inadequate intake of folic acid is either absolute, i. e. a reduced intake in food, or relative, i. e. disorders of its metabolism. MTHFR mutations are among the most significant metabolic disorders. A relative or absolute deficiency of folic acid may be linked with various gestational pathologies. No exact associations have been known so far; however, recent information has shown that metafolin...

The question of pharmacological treatment in selected diseases and drug groups

David Suchý, Milan Hromádka

Prakt. lékáren. 2011; 7(4): 172-175  

Elderly patiens are more than twice as susceptible to averse drug reaction as younger patiens. These reactions are likely to be more serious and extend hospitalization longer, that for a younger patiens. Changes with aging in body composition, and in drug metabolism, distribution, excretion and response are the reasons for greater vulnerability observed in this patiens. Use of potentially inappropriate medication in elderly patiens is a major health care concern. There is need avoiding medications with a high potential for averse events and recommended alternatives with lower risc.

Denosumab

Petr Hrdý, Pavel Novosad

Prakt. lékáren. 2011; 7(4): 158-159  

Denosumab is a fully human recombinant monoclonal antibody (IgG2), that inhibits bone resorption by blocking receptor activator of nuclear factor kappaB ligand (RANK ligand, RANKL), which is the key mediator of function, formation and surviving of osteoclasts. Therapy of denosumab leads to risk reduction of vertebral and nonvertebral fractures the same way as fractures of proximal femur, which was demonstrated in big multicentric study against the placebo (study FREEDOM). As well the therapy of denosumab leads to significant rising of BMD in compare to active drug (studies DECIDE and STAND). Denosumab is administered parenteral, once every...

Palliative medicine from the perspective of a clinical pharmacist

Jana Gregorová

Prakt. lékáren. 2011; 7(4): 180-181  

Pharmacology of palliative medicine is not only interesting of most frequently used drugs groups, but often severe condition. In palliative medicine is a multidisciplinary team in place for clinical pharmacists, who can help in optimizing drug regimens of patients.

Magnolia, Crocus sativus.

Zdeňka Navrátilová

Prakt. lékáren. 2011; 7(4): 191-194  

Natural antidepressants Mood disorders, mainly depression, are nowadays one of the most frequent mental illnesses. Although there are many antidepressants with different mechanism of action on the market, in cases of mild depression herbal remedies can be used. The article describes selected plants with antidepressant effect – Hypericum perforatum, Sceletium tortuosum, Panax ginseng, Rhodiola rosea, Magnolia and Crocus sativus. Some of them are already used in the therapy, others may be used in the future. Some plants are available for sale as dietary supplements. Magnolia, Crocus sativus.

Almond oil in extemporaneous prescription

Jan Hašek

Prakt. lékáren. 2011; 7(4): 176-179  

Almond oil contains 20−30 % of linoleic acid glycerides present in several types of ceramides. The article discusses the importance of lipids as a component of emollients and their effect on the skin barrier. Almond oil is an available pharmaceutical raw material and can be formulated in extemporaneous preparations intended for adjuvant therapy of dermatitides and for skin care. Also included are formulas for class I topical corticosteroids, containing an oleophilic base with almond oil, that are particularly suitable in paediatric practice.

Oral hygiene in children

Vlasta Merglová

Prakt. lékáren. 2011; 7(4): 182-186  

In this article, the author introduce various instruments of oral hygiene in children and presents different toothbrushing techniques recommended in each age category. Toothbrushes, interdental hygiene tools, toothpastes and mouthwashes are described in details. Parents have a highly important role in oral hygiene of their children, since not only could be a good example to their own children but also because they teach their children to clean properly their teeth, they assist during toothbrushing, they supervise the implementation of oral hygiene and they provide with motivatation their children for keeping their oral hygiene in good standards.

Prebiotics and infant nutrition

Josef Sýkora

Prakt. lékáren. 2011; 7(4): 187-190  

This paper focuses on the well-known health benefits and the potential uses of prebiotics in infant feeding featuring well-designed and carefully conducted randomised controlled trials.

Pátek třináctého nebyl pro lékárníky nešťastný

Mgr. Jitka Strouhalová

Prakt. lékáren. 2011; 7(4): 197  

Aedificatum a. d. MCMIX - historie bohnické psychiatrie v letech 1909-2009

Jan Pomykacz

Prakt. lékáren. 2011; 7(4): 195-196  

Autodidaktický test 4/2011

Prakt. lékáren. 2011; 7(4): 198-199