Prakt. lékáren. 2021; 17(2): 129-134 | DOI: 10.36290/lek.2021.023

Vaginal medicinal preparations available in the Czech Republic and the basic principles of their application

Andrej Kováčik, Barbora Vraníková
Katedra farmaceutické technologie, Farmaceutická fakulta UK v Hradci Králové

Vaginal application of drugs is most often used in local therapy of bacterial or fungal infections or to restore the physiological pH of the vaginal mucosa in adolescent and adult women. Vaginal preparations are also utilized to achieve a systemic effect, especially, after administration of hormones (e. g., contraception, assisted reproduction). This article aims to briefly characterize vaginal dosage forms, introduce available commercial medicinal products for vaginal administration and summarize the basic principles of applying vaginal dosage forms.

Keywords: vaginal application, pessaries, vaginal inserts, vaginal tablets, semi-solid vaginal dosage forms.

Published: August 5, 2021  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Kováčik A, Vraníková B. Vaginal medicinal preparations available in the Czech Republic and the basic principles of their application. Praktické lékárenství. 2021;17(2):129-134. doi: 10.36290/lek.2021.023.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Koliba P, Příhodová V. Možnosti farmaceuta v léčbě vulvo-vaginální kandidózy. Prakt. Lékáren., 2014; 10(3): 95-98.
    2. Koliba P. Vaginální kandidóza - současné možnosti diagnostiky a léčby. Dermatol. Praxi, 2014; 8(2): 68-70.
    3. Koliba P, Koliba P jr. Vaginální dyskomfort, intimní hygiena. Prakt. Lékáren., 2013; 9(3): 139-141.
    4. Turčan P. Nové možnosti v léčbě bakteriální vaginózy a vaginálního dyskomfortu. Prakt. Lékáren., 2011; 7(5): 208-210.
    5. Pendergrass PB, Belovicz MW, Reeves CA. Surface area of the human vagina as measured from vinyl polysiloxane casts. Gynecol. Obstet. Invest., 2003; 55(2): 110-113. Go to original source... Go to PubMed...
    6. Aulton M, Taylor K. Aulton's Pharmaceutics: The Design and Manufacture of Medicines, Amsterdam: Elsevier Health Sciences, 2017.
    7. Alexander NJ, Baker E, Kaptein M, Karck U. Why consider vaginal drug administration? Fertility and Sterility, 2004; 82(1): 1-12. Go to original source... Go to PubMed...
    8. Roztočil A, et al. Moderní porodnictví, Praha: Grada Publishing, 2008.
    9. Fahr A. Voigt's Pharmaceutical Technology, Hoboken: John Wiley & Sons, 2018.
    10. Český lékopis 2017: Pharmacopoea Bohemica MMXVII (Ph. B. MMXVII). 4. díl, Evropská část. Praha: Grada Publishing, 2017.
    11. SPC: Státní ústav pro kontrolu léčiv dostupné z: www.sukl.cz (10. 05. 2021).
    12. SPC Rosalgin dostupné z: https://www.sukl.cz/modules/medication/detail.php?kod=0132725 (10. 05. 2021).
    13. WWW stránky dostupné z: https://www.rpshop.cz/ (10. 05. 2021).
    14. WWW stránky dostupné z: https://www.rosalgin.cz/ (10. 05. 2021).
    15. WWW stránky dostupné z: https://www.gynella.com/produkt/gynella-silver-foam/ (10. 05. 2021).
    16. WWW stránky dostupné z: http://www.farmaderma.it/en (10. 05. 2021).
    17. SPC Lomexin dostupné z: https://www.sukl.cz/modules/medication/detail.php?kod=0076547 (10. 05. 2021).
    18. Sklenář Z, Hašek J. Nové léčivé látky v magistraliter receptuře I - Nystatin. Prakt. Lékáren., 2010; 6(1): 30-35.
    19. Gajdziok J, Vetchý D. Mukoadhezivní polymery v lékových formách. Chem. Listy, 2012; 106: 632-638.
    20. Knuth K, Amiji M, Robinson JR. Hydrogel delivery systems for vaginal and oral applications. Adv. Drug Deliv. Rev., 1993; 11: 137-167. Go to original source...
    21. Dvořáčková K, Rabišková M. Vaginální aplikace léčiv - nové směry. Prakt. Lékáren., 2006; (2): 93-97.
    22. Vaníček J. Správné užívání a aplikace léků. Doporučené Postupy České Lékárnické Komory pro Konzultační Činnost v Lékárnách, 2010: 21-37.
    23. Cramer DW, Liberman RF, Titus-Ernstoff L, Welch WR, Greenberg ER, Baron JA, Harlow BL. Genital talc exposure and risk of ovarian cancer. Int. J. Cancer, 1999; 81(3): 351-356. Go to original source...
    24. SPC Vagifem dostupné z: https://www.sukl.cz/modules/medication/detail.php?kod=0145124 (10. 05. 2021).
    25. Novotná M. Moderní trendy v hormonální antikoncepci. Med. Praxi., 2011; 8(12): 544-546.
    26. Fanta M. Trendy v hormonální antikoncepci. Prakt. Lékáren., 2010; 6(6): 291-293.
    27. SPC Adaring dostupné z: https://www.sukl.cz/modules/medication/detail.php?code=0223802&tab=texts (10. 05. 2021).

    Return to the content


    Pharmacy for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.