Spolek farmaceutů v Hradci Králové

Jiří Kotlář

Prakt. lékáren. 2019; 15(3): 123  

New options in diagnostics and treatment of familial hypercholesterolemia

Šárka Tesařová, Michal Vrablík

Prakt. lékáren. 2019; 15(3): 134-139  

Familial hypercholesterolaemia (FH) is the most frequent AD hereditary disease, leading to higher levels of total cholesterol and LDL-cholesterol (LDL-C). We distinguish two forms of this disease, heterozygous and rare homozygous. This disease could be longterm asymptomatic and CVD manifestation (the most frequently ischemic heart disease) is often the first sign and it comes sooner than in common population. Diagnostic milestone is anamnesis (especially family and personal) and thorough physical examination. By scoring systems we can classify probability of FH, Dutch Lipid Clinic Network Criteria is mostly used in the Czech Republic. In case of FH...

Inflammation as a part of the pathophysiology of depression and the possibility of its influence by polyunsaturated fatty acids

Hana Kotolová, Tomáš Hammer

Prakt. lékáren. 2019; 15(3): 140-143  

Depression and other affective disorders are among the most prevalent mental disorders. The pathophysiology of this diseaseis complex, and pro-inflammatory processes appear to play an important role in it. The article aims to summarize the existingknowledge of the research of the interconnection of affective disorders and inflammation and their possible influence by recentlyhighly discussed polyunsaturated fatty acids.

Paracetamol: looking for an optimal dose

Jiří Slíva

Prakt. lékáren. 2019; 15(3): 144-147  

Analgesics are among the most commonly used drug classes. Each of them has its specific features, advantages as well asweaknesses in terms of possible adverse effects or drug interactions. In order to achieve the therapeutic response required, it isessential to choose the correct therapeutic dose. This also applies to paracetamol, a non-opioid analgesic. The present text placesthis agent into a historical context as well as highlights the situation in the Czech Republic in terms of its use – the preferencesregarding the dose, risks of underdose, overdose, etc.

Vitiligo: diagnosis and therapy

Karolína Bortelová

Prakt. lékáren. 2019; 15(3): 148-152  

Vitiligo is a skin disorder resulting in the appearance of white, sharply delimited macules on the skin. It is usually diagnosed clinically, although in case of ambiguity, Wood lamp or skin biopsy can be used. There are currently many options for vitiligo therapy, local preparations, phototherapy and surgical treatment are available. Local corticosteroids or topical immunomodulators for localized vitiligo and phototherapy for generalized vitiligo are considered as the first choice. Since treatment often takes a long time, and not always a cosmetically acceptable result, we encounter patients with frustration and increased mental stress, so it is good...

Symptoms associated with chronic venous disease: how can a pharmacist help?

Gabriela Kroupová

Prakt. lékáren. 2019; 15(3): 153-156  

Chronic venous disease is a serious, progressive condition with a high morbidity. In addition to signs, venous disease is accompanied by a number of symptoms, such as leg pain, feeling of tired and heavy legs, tingling, cramps, and swelling. Since patients often seek help in the pharmacy first, a pharmacist’s role is to educate on possible implications of venous disease and recommend the need for being examined by a general practitioner, skin or vascular specialist. A pharmacotherapy that is correctly chosen, effective, verified, and initiated early results in symptom relief, reduction in leg swelling, improved quality of life of patients, and...

Tolvaptan

Jan Miroslav Hartinger

Prakt. lékáren. 2019; 15(3): 129-132  

Tolvaptan is a vasopressin V2 receptor blocker that increases free water excretion without affecting the rate of sodium excretion. It is a diuretic with a unique mechanism of action that is primarily used in treating the syndrome of inappropriate antidiuretic hormone secretion and in the treatment of autosomal dominant polycystic kidney disease. With tolvaptan treatment, the risk of drug interactions must be kept in mind, since it is a CYP3A4 substrate. Moreover, particularly at the beginning of treatment, it is necessary to frequently check liver tests and mineral panel as well as educate patients on the need for sufficient hydration and secure access...

Black garlic – active compounds and therapeutic effects

Zdeňka Navrátilová

Prakt. lékáren. 2019; 15(3): 158-166  

Healing properties of garlic (Allium sativum L.) are known for thousands of years. Black garlic is obtained from fresh garlic that has been fermented for a period of time at a high temperature and under high humidity. In contrast to fresh garlic, black garlic does not have a typical pungent flavour and aroma. Not only sensory properties are changing during the fermentation but also a chemical composition. As compared with fresh garlic, black garlic possesses an abundant amount of antioxidant compounds such as polyphenols, flavonoids, and organosulfur compounds, including stable water-soluble S-allyl cysteine and S-allyl mercaptocysteine. These...

Glycaemic index od foods 2019

Rudolf Chlup, Karolina Peterson, Pavla Kudlová, Jiří Nečas

Prakt. lékáren. 2019; 15(3): 172-177  

This review is dealing with (1) basic parameters of hyperglycaemic power of food products, (2) various factors influencing thehyperglycaemic power of food, (3) methods of measurement of classical and extended glycaemic indexes (4) food products witha low-, medium- and high glycaemic index and (5) input of the glycaemic index in treatment of various diseases and in physicaltraining. Important references and results of authors´ observations are included.

Hospital pharmacy, part of the University Hospital Hradec Králové, the provider of pharmacy care and clinical pharmacy care, the workplace, which is not only accreditted for three pharmacy specializations

Martina Maříková

Prakt. lékáren. 2019; 15(3): 181-185  

Hospital pharmacy is a part of the functional unit of University Hospital in Hradec Králové. It is the largest pharmacy in east Bohemiaand it is the only facility in the Hradec Králové Region to provide 24hour pharmacy emergency service. Hospital pharmacy providesbasic and specialized pharmacy care for about 700, 000 outpatients and 41, 000 in patients a year. The Department of Clinical Pharmacy,which is organizationally integrated in Hospital Pharmacy, provides clincal-pharmaceutical care for hospitalized patients.

Probiotics for prevention of infections preeschol – agend children in day care centers

Pavel Frühauf

Prakt. lékáren. 2019; 15(3): 178-180  

Participation in center-based child care among preschool-aged children is associated with an increased incidence of communicableillness. The author systematically reviewed data from randomized controlled trials to investigate the effect of probioticconsumption on infections in children in day care centers.

Functional digestive disorders, phytotherapy by preparation STW 5 (Iberogast®)

Vít Navrátil

Prakt. lékáren. 2019; 15(3): 162-166  

Dyspepsia is one of the most common cause of visiting a pharmacy or a physician. It is a heterogenous group of unpleasant symptoms concerning the digestive tract, abdomen, intake of food and bowel movement. Subject of the first part of the article is a brief review of digestive disorders, especially functional disorders, and a brief classification of them. Moreover it contains a summary of treatment possibilities. STW 5 (Iberogast®) is a fixed herbal combination product, available as a over-the-counter medicine. It is an effective, safe and well tolerated medicine. The second part of the article concerns with composition and data summary about...

Topical treatment of pain – The current OTC products overview

Jana Martinásková

Prakt. lékáren. 2019; 15(3): 167-171  

Self-medications of musculosceletal tract painful conditions represent frequent visits of the pharmacy by the patients. This type of pain can be treated by either an oral or topical forms of non-steroidal anti-inflammatory drugs (NSAIDs). In view of the fact that oral NSAIDs have systemic side effects and possible drug interactions, in most cases it is suitable to recommend the topical form as a first choice. The advantage of topical formulations of NSAIDs include the selective acting in affected area and minimization of the risks of systemic side effects, for example gastrointestinal complications. In the pharmacy the advising is provided associated...

Test 3/19

Prakt. lékáren. 2019; 15(3): 186-187