Abstrakta: 1. kongres Farmacie pro praxi / 8.–9. září 2023, Brno

Solen, s. r. o., a časopis Farmacie pro praxi

Farmacie pro praxi. 2023;19(Suppl.B)  

Abstrakta: 17. KONGRES PRAKTICKÉHO LÉKÁRENSTVÍ / 21.–22. dubna 2023, Olomouc

Solen, s. r. o., a časopis Farmacie pro praxi

Farmacie pro praxi. 2023;19(Suppl.A)  

The progression of vaccines - where it's going, sorts, effect, new recommendationsCurrent pharmacotherapy#E-version

MUDr. Pavel Slezák

Farmacie pro praxi. 2023;19(4):e14-e17  

The development of vaccines, types, effects, new recommendations. Vaccination is one of the greatest discoveries in the field of medicine. Although vaccination has a long history, it is still evolving, and the development is accelerating. The article is a methodical introduction to the issue of vaccination with a focus on adults. It describes the basic directions of vaccine development, types of vaccines, and the basic principles of their effect. In the conclusion, basic recommendations for vaccination of adults are formulated: comply with prescribed regular vaccinations, recommend seasonally important vaccinations, vaccinate pregnant women, focus...

Flucloxacillin pharmacokinetic propertiesCurrent pharmacotherapy#E-version

Vendula Kubíčková, Vladimíra Vojtová, Karel Urbánek

Farmacie pro praxi. 2023;19(4):e9-e13  

Flucloxacillin is a semi-synthetic betalactam antibiotic from the group of isoxazolylpenicillins. It differs from oxacillin by the attachment of one fluorine-chlorine atom to the benzene nucleus which improves absorption from the GIT and prolongs its biological half-life. Its bioavailability is 54-79 %, volume of distribution is 0.14 ± 0.14 l/kg, and plasma protein binding is 92-95%. It is only about 10 % metabolised, 75 % excreted by the kidneys via glomerular filtration and tubular secretion with a half-life of 0.75-1.14 h. Dosage ranges from 500 mg every 8 h PO to 2 g every 4 h IV, depending on the severity of the condition and patient characteristics,...

Antibiotic allergiesCurrent pharmacotherapy#E-version

MUDr. Lenka Sedláčková

Farmacie pro praxi. 2023;19(4):e4-e8  

Antibiotic allergies represent a growing issue in the current medicine. They limit treatment options, and not always justifiably. The majority of cases is labelled as having penicillin allergy. However, penicillin allergy is up to ten times overdiagnosed. The true allergy confirmation is based on detailed analysis of the course of the adverse event, skin tests, and, selectively, laboratory and provocation tests. This paper offers a review of clinical manifestations and a basic orientation in diagnosis and management of antibiotic allergies.

Klatovy byly k lékárníkům přívětivéInformation

PharmDr. Pavel Grodza

Farmacie pro praxi. 2023;19(4):263-264  

Kombinace uhličitanů a extraktu z opuncie má synergický účinekCompany information

MUDr. Andrea Skálová

Farmacie pro praxi. 2023;19(4):260-262  

Změna je životEditorial

PharmDr. Pavel Grodza

Farmacie pro praxi. 2023;19(4):207  

Herbal capsules to increase breast milk production - their effects and risksPhytotherapy

Eva Novák Doubravová

Farmacie pro praxi. 2023;19(4):255-259  

Lactating women are often accompanied by a feeling of lack of breast milk, but this may not correspond to objective reality. One of the traditionally recommended means to increase the production of breast milk are herbal capsules containing fenugreek, alone or in combination with other herbs. The question is whether the use of these herbs can really affect breastfeeding and whether it does not have any negative effects on the mother or her nursing baby.

Current recommendations to patients for self-treatment of seasonal respiratory diseasesSelf-treatment

Karel Hrnčiarik, Martina Kůtková

Farmacie pro praxi. 2023;19(4):248-253  

Common seasonal respiratory disease suitable for self-treatment is an uncomplicated upper respiratory tract disease caused by common viruses. The most effective treatment for seasonal respiratory disease is comprehensive therapy, i.e. not only suppression of symptoms with active agents, but also an often neglected appropriate regimen.

Medical devices in wound healing IV: Hydrogels, hydrocolloids and hydrofibersMedical devices

Barbora Vraníková, Andrej Kováčik

Farmacie pro praxi. 2023;19(4):240-247  

Wound healing represents a key process in maintaining the stability of the internal environment of the human organism. It is generally known that this process consists of several stages, which should be actively supported by a properly selected wound dressing. However, devices intended for traditional wound healing (dressings made of gauze and non-woven fabric) are not able to maintain a suitable microenvironment in the wound. For this reason, these devices are often replaced by modern dressings intended for moist wound healing. Thus, the aim of this article is to introduce three subgroups of modern dressings for moist healing, namely hydrogels, hydrocolloids...

Biological activities of vitamin DMedical devices

Lenka Bartošíková, Jiří Nečas

Farmacie pro praxi. 2023;19(4):232-239  

Vitamin D has long been known for its role in calcium homeostasis for optimal skeletal health. The discovery of vitamin D and its role in preventing rickets is attributed to Elmer McCollum, a nutritional biologist at Johns Hopkins, and John Howland, a pediatrician. Vitamin D represents a group of lipophilic secosteroids responsible for the increased absorption of calcium, magnesium and phosphates in the intestines and the subsequent mineralization of bone, and for many other extra-skeletal effects. Recent data include xenobiotic detoxification, oxidative stress reduction, neuroprotective functions, antimicrobial effects, immunoregulation, anti-inflammatory/anticancer,...

Treatment of chronic pain-up to dateCurrent pharmacotherapy

MUDr. Pavlína Nosková, Ph.D.

Farmacie pro praxi. 2023;19(4):226-231  

Chronic pain is a serious health problem that puts a strain on the entire health system. Her treatment should be conducted rationally and on the basis of current scientific knowledge. The article summarizes the current view of this issue and points to new painkillers and recommendations.

Current trends in the use of bacterial lysatesCurrent pharmacotherapy

Zuzana Humlová

Farmacie pro praxi. 2023;19(4):220-225  

Bacterial lysates stimulate the general immunity of the body in a non-specific way. They act on non-specific defense mechanisms, leading to an increase IgA in mucous membranes, phagocytic activity and interferon gamma production. They can also stimulate the production of specific antibodies against the bacterial antigens that make up the preparation. In many clinical trials, oral bacterial lysates have been shown to decrease the risk of recurrent respiratory infections in children and adults and reduce the need for antibiotics.

Acute upper respiratory tract infections - diagnosis and treatementCurrent pharmacotherapy

Karolina Edelmannová

Farmacie pro praxi. 2023;19(4):216-219  

Inflammation of the oropharynx is one of the most common infections across all age categories. The oropharynx, which contains a large amount of lymphatic tissue participating in the defense against external influences, is the gateway for infections. Most inflammations of the oropharynx are of viral origin, so over-the-counter preparations containing substances with a disinfecting and local numbing effect are sufficient. It is also advisable to recommend the overall use of analgesics and antipyretics to treat all symptoms and, of course, a regimen of measures such as bed rest and plenty of fluids. In the case of bacterial inflammations, sometimes we...

The role of metformin in the treatment of diabetes in pregnancyCurrent pharmacotherapy

Ondřej Krystyník

Farmacie pro praxi. 2023;19(4):211-215  

Excelent metabolic control is essential for the successful course of pregnancy in women with both pregestational and gestational diabetes. However, in contrast to the non-pregnancy period, pharmacological options for the treatment of diabetes are limited. Compared with insulin, metformin offers a number of practical advantages, such as an oral route of administration, easy training and the low price. Although it crosses the placenta, its use is probably not associated with a risk of fetal harm in early pregnancy. Large randomized trials suggest several positive metabolic consequences of metformin use in pregnancy. These include lower maternal weight...

Drug interactions of medications used in the therapy of erectile dysfunction with dietary supplementsCurrent pharmacotherapy#E-version

Josef Suchopár, Štěpán Suchopár, Michal Prokeš

Farmacie pro praxi. 2023;19(3):e15-e19  

Herbal products, or food supplements made from them, can lead to drug interactions as well as drugs. However, manufacturers of such food supplements do not point out possible drug interactions. Phosphodiesterase type 5 (iPDE5) inhibitors are widely used drugs, the common feature of which is degradation by the CYP3A4 and CYP3A5 pathways. Inhibitors and inducers of these cytochrome P-450 isoenzymes cause drug interactions of varying severity, and only for some of them is it possible to find a recommended management in the SPC. The aim of the article is to provide basic information about herbal products with the potential to influence pharmacokinetics...

Drug treatment of hypertension in pregnancyCurrent pharmacotherapy#E-version

Renata Cífková

Farmacie pro praxi. 2023;19(3):e10-e14  

Hypertension is the most frequent non-obstetric complication effecting about 10% of pregnancies. Hypertension in pregnancy is classified as either pre-existing (chronic) or gestational, developing after 20 weeks of gestation and usually resolving within 6 weeks postpartum. Systolic blood pressure ≥ 170 mmHg or diastolic blood pressure ≥ 110 mmHg are considered an emergency and hospitalization is indicated. The selection of antihypertensive drugs and the way they are administered depend on blood pressure values, gestational age and the estimated time of delivery. According to the current European and Czech guidelines, initiation of drug...

Serious states induced by taking psychopharmacs and their treatmentCurrent pharmacotherapy#E-version

Eva Češková, Kateřina Horská

Farmacie pro praxi. 2023;19(3):e4-e9  

The article summarizes current knowledge of severe states associated with taking antidepressants and antipsychotics. These states usually require immediate intervention and include acute and tardive dystonia, tardive dyskinesias, neuroleptic malignant syndrome, serotonin syndrome and withdrawal-induced syndrome. Regarding their severity, and sometimes unexpectedly manifestation, they represent severe adverse events subjected to compulsory reporting to State Institute for Drug Control, Department of Pharmacovigilance.

Jak se vyznat v nových formách nikotinuEditorial

prof. MUDr. Eva Králíková, CSc.

Farmacie pro praxi. 2023;19(3):143  

V Polné odkrývají příběhy staré lékárnyPress Release

Jan Štěpánek

Farmacie pro praxi. 2023;19(3):200  

Racekadotril v samoléčbě akutního průjmu u dospělýchCompany information

PharmDr. Markéta Musilová

Farmacie pro praxi. 2023;19(3):197-198  

Prevention and therapy of influenza conditions: some modalitiesCompany information

MUDr. Pavel Kostiuk, CSc., PharmDr. Lucie Kotlářová, PharmDr. Zdeněk Procházka

Farmacie pro praxi. 2023;19(3):192-196  

Viral respiratory diseases (regardless of the type of the causing virus), which are manifested by a clinical picture resembling influenza (high temperature, cough, sore throat) are referred to as "influenza-like illness" (ILI), or flu conditions. Treatment of these diseases is usually symptomatic (except for antiviral drugs that can be used for "true" flu). Due to the dominant role of the state of the immune system in the development and course of these diseases, immunostimulation has a dominant position in prevention and treatment. One possibility is the flu vaccination, but this only targets the "true" flu, while not affecting the risk of other ILIs....

Varicella-recommended treatment in pharmacySelf-treatment

Jana Kopuletá

Farmacie pro praxi. 2023;19(3):188-190  

Varicella (chicken pox) is one of the most common acute infectious diseases of childhood. It is caused by primary infection with the herpes varicella zoster virus (VZV) of the subfamily Alphaherpesvirinae. This group of DNA viruses is characterized by rapid reproduction, perineural spread, the ability of latency and subsequent reactivation. After experiencing varicella, the virus persists in the nerve ganglia and manifests itself as herpes zoster (shingles) upon reactivation. Typically, varicella occurs in the form of generalized polymorphic seeding on the skin - exanthema and mucous membranes - enanthema. In childhood the disease usually has a mild...

Self treatment of insomniaSelf-treatment

Olga Nedopílková, Šárka Močidlánová

Farmacie pro praxi. 2023;19(3):182-186  

Insomnia is a main sleep disorder that significantly disrupts an individual's daily activity. Poor-quality or insufficient sleep can lead to fatigue, work inefficiency, a decrease in daytime vigilance, and even impaired cognitive functions. Good sleep is perceived as one of the basic attributes of good health. Therefore, information about insomnia should always be paid close attention to

Prickly pear cactus - active compounds and therapeutic effectsPhytotherapy

Zdeňka Navrátilová

Farmacie pro praxi. 2023;19(3):177-181  

Opuntia ficus-indica (prickly pear) is a shrubby cactus which originates from Mexico. It gives edible fruits known as Indian figs, cactus figs or prickly pears. All parts of plant (stem cladodes, flowers, fruits, seeds, roots) contain many bioactive compounds with numerous pharmacological activities. Prickly pear cactus has wide use not only in traditional medicine and modern studies often confirm its therapeutic effects. The article summarizes current knowledge about bioactive compounds and potential therapeutic effects of prickly pear.

Limitations of idarucizumab efficacy in acute renal failure - a case reportCase reports from the pharmaceutical practice

Jitka Rychlíčková, Tomáš Trávníček, Tereza Jelínková, Jan Žák

Farmacie pro praxi. 2023;19(3):173-176  

Idarucizumab, a monoclonal antibody fragment capable of binding dabigatran molecules in a 1 : 1 stoichiometric relationship, is a specific antidote for dabigatran. The dose of idarucizumab was estimated based on observed plasma concentrations of dabigatran to achieve immediate, complete, and sustained reversal of the anticoagulant effect of dabigatran. Currently, a single dose of 5 g intravenously is recommended. However, in certain situations, the capacity of idarucizumab may be exhausted, and dabigatran plasma concentrations may rise again within hours of initial administration. We illustrate one such situation with a patient with acute renal failure,...

Monoclonal antibodies in neurology - treatment of multiple sclerosis and migrainesCurrent pharmacotherapy

Olga Bartošová

Farmacie pro praxi. 2023;19(3):168-171  

Monoclonal antibodies have become a mainstay in the treatment of patients with multiple sclerosis. Their mechanism of action targets distinct immune mechanisms of multiple sclerosis pathophysiology. Natalizumab acts by binding to cell surface receptors and thus prevents the migration of leukocytes across the blood-brain barrier. Alemtuzumab, rituximab, ocrelizumab, ofatumumab and ublituximab eliminate a selected population of pathogenic cells. Opicinumab acts as a transmembrane signaling protein (LINGO-1) antagonist. These drugs are an important pillar in the treatment of scattered. However, potential side effects can be serious and may require discontinuation...

Current trends in treatment of atopic dermatitis - a minimum for pharmacistsCurrent pharmacotherapy

Petra Brodská

Farmacie pro praxi. 2023;19(3):162-166  

Atopic dermatitis is a common, chronic, relapsing inflammatory skin disease. The complex of different interactions between individual genetic predisposition to atopic diseases (bronchial asthma, allergic rhino-conjunctivitis, and food or inhalant allergy), environmental factors, epidermal barrier dysfunction and abnormalities of the immune system with predominance Th2 response are involved. Treatment of moderate to severe atopic dermatitis could be challenging. Over the last few years, new advances in the understanding of atopic dermatitis pathogenic mechanisms and inflammatory pathways have led to the identification of specific therapeutic targets...

Current trends in COPD treatmentCurrent pharmacotherapy

Ondřej Zela

Farmacie pro praxi. 2023;19(3):158-161  

COPD (chronic obstructive pulmonary disease) ranks globally among the most frequent chronic respiratory diseases, affecting approximately 8 % of world population and is strongly associated with smoking. In the Czech republic, about 30 % of population over 15 years are smokers, spending almost 120 billion CZK (equivalent of 5.5 billion USD) every year on tobbaco products (about 11,000 CZK/500 USD per capita). COPD is one of the major diseases routinely treated by pulmonologists. About 300,000 patients are unaware of their condition and thus untreated. The purpose of the following text is to highlight the basic principles of modern COPD treatment.